{"title":"生物打印水凝胶在骨再生：文献计量学分析。","authors":"Huijie Zhang, Xiaoyu Li, Zhenyu Jia, Kun Jiao, Chen Liu, Zixiang Deng, Yushu Bai, Xianzhao Wei, Xiaoyi Zhou","doi":"10.3389/fphar.2025.1532629","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The application of bioprinted hydrogels in the field of bone regeneration is garnering increasing attention. The objective of this study is to provide a comprehensive overview of the current research status, hotspots and research directions in this field through bibliometric methods, and to predict the development trend of this field.</p><p><strong>Methods: </strong>A search was conducted on 27 December 2024, for papers published on the Web of Science from 2010 to 2025. We used the bibliometrix package in the software program R to analyze the retrieved data and VOSviewer and CiteSpace to visualize hotspots and research trends in bioprinted hydrogels for bone regeneration.</p><p><strong>Results: </strong>We identified and reviewed 684 articles published in this field between 2010 and 2025. A total of 811 institutions and 1,166 researchers from 41 countries/regions contributed to these publications. Among them, China led in terms of the number of articles published, single-country publications (SCP), and multi-country publications (MCP). Our bibliometric-based visualization analysis revealed that the mechanical properties and osteogenic differentiation capacity of biomaterials have been a focal research topic over the past decade, while emerging research has also concentrated on the <i>in vitro</i> fabrication of stem cells for bone regeneration and osteogenic differentiation, particularly the precise application of <i>in situ</i> stem cell-loaded bioprinted organoids.</p><p><strong>Conclusion: </strong>This study provides an in-depth analysis of the research trajectory in the application of bioprinted hydrogels for bone regeneration. The number of research papers in this field is increasing annually, and the main research hotspots include bone regeneration, 3D printing, scaffolds, and hydrogels. Future research directions may focus on gelatin, additive manufacturing, and growth factors. Additionally, international collaboration is essential to enhance the effectiveness of bioprinted hydrogels in bone regeneration applications.</p>","PeriodicalId":12491,"journal":{"name":"Frontiers in Pharmacology","volume":"16 ","pages":"1532629"},"PeriodicalIF":4.8000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830744/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bioprinted hydrogels in bone regeneration: a bibliometric analysis.\",\"authors\":\"Huijie Zhang, Xiaoyu Li, Zhenyu Jia, Kun Jiao, Chen Liu, Zixiang Deng, Yushu Bai, Xianzhao Wei, Xiaoyi Zhou\",\"doi\":\"10.3389/fphar.2025.1532629\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The application of bioprinted hydrogels in the field of bone regeneration is garnering increasing attention. 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Our bibliometric-based visualization analysis revealed that the mechanical properties and osteogenic differentiation capacity of biomaterials have been a focal research topic over the past decade, while emerging research has also concentrated on the <i>in vitro</i> fabrication of stem cells for bone regeneration and osteogenic differentiation, particularly the precise application of <i>in situ</i> stem cell-loaded bioprinted organoids.</p><p><strong>Conclusion: </strong>This study provides an in-depth analysis of the research trajectory in the application of bioprinted hydrogels for bone regeneration. The number of research papers in this field is increasing annually, and the main research hotspots include bone regeneration, 3D printing, scaffolds, and hydrogels. Future research directions may focus on gelatin, additive manufacturing, and growth factors. 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引用次数: 0
摘要
背景：生物打印水凝胶在骨再生领域的应用越来越受到关注。本研究的目的是通过文献计量学方法对该领域的研究现状、热点和研究方向进行全面概述，并对该领域的发展趋势进行预测。方法：检索Web of Science 2010 - 2025年间发表的论文，检索时间为2024年12月27日。我们使用R软件中的bibliometrix软件包分析检索到的数据，并使用VOSviewer和CiteSpace可视化生物打印水凝胶用于骨再生的热点和研究趋势。结果：我们检索并回顾了2010 - 2025年间在该领域发表的684篇文章。来自41个国家/地区的811个机构和1166名研究人员对这些出版物做出了贡献。其中，中国在论文发表数量、单一国家出版物（SCP）和多国出版物（MCP）方面均居首位。我们基于文献计量学的可视化分析显示，生物材料的力学性能和成骨分化能力在过去十年中一直是研究的焦点，而新兴的研究也集中在体外制造用于骨再生和成骨分化的干细胞，特别是原位干细胞负载生物打印类器官的精确应用。结论：本研究对生物打印水凝胶用于骨再生的研究轨迹进行了深入分析。该领域的研究论文数量逐年增加，主要研究热点包括骨再生、3D打印、支架、水凝胶等。未来的研究方向可能集中在明胶、增材制造和生长因子方面。此外，国际合作对于提高生物打印水凝胶在骨再生应用中的有效性至关重要。
Bioprinted hydrogels in bone regeneration: a bibliometric analysis.
Background: The application of bioprinted hydrogels in the field of bone regeneration is garnering increasing attention. The objective of this study is to provide a comprehensive overview of the current research status, hotspots and research directions in this field through bibliometric methods, and to predict the development trend of this field.
Methods: A search was conducted on 27 December 2024, for papers published on the Web of Science from 2010 to 2025. We used the bibliometrix package in the software program R to analyze the retrieved data and VOSviewer and CiteSpace to visualize hotspots and research trends in bioprinted hydrogels for bone regeneration.
Results: We identified and reviewed 684 articles published in this field between 2010 and 2025. A total of 811 institutions and 1,166 researchers from 41 countries/regions contributed to these publications. Among them, China led in terms of the number of articles published, single-country publications (SCP), and multi-country publications (MCP). Our bibliometric-based visualization analysis revealed that the mechanical properties and osteogenic differentiation capacity of biomaterials have been a focal research topic over the past decade, while emerging research has also concentrated on the in vitro fabrication of stem cells for bone regeneration and osteogenic differentiation, particularly the precise application of in situ stem cell-loaded bioprinted organoids.
Conclusion: This study provides an in-depth analysis of the research trajectory in the application of bioprinted hydrogels for bone regeneration. The number of research papers in this field is increasing annually, and the main research hotspots include bone regeneration, 3D printing, scaffolds, and hydrogels. Future research directions may focus on gelatin, additive manufacturing, and growth factors. Additionally, international collaboration is essential to enhance the effectiveness of bioprinted hydrogels in bone regeneration applications.
期刊介绍：
Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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