n型钙通道从灰烬中升起。

IF 14.3 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Clinical Investigation Pub Date : 2025-02-17 DOI:10.1172/JCI189308

Maria A Gandini, Gerald W Zamponi

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引用次数: 0

摘要

慢性疼痛是一种使人衰弱的疾病，影响着全球多达15亿人。推进疼痛管理取决于对患者所经历的疼痛类型和驱动疼痛的潜在机制的透彻理解。n型钙通道作为治疗慢性疼痛的靶点起着至关重要的作用。在本期《JCI》中，Tang等人介绍了一种n型钙通道阻滞剂C2230，它在高频刺激时抑制CaV2.2通道，对多种模型疼痛通路中的其他离子通道影响不大。C2230是一种很有前景的用于治疗干预的镇痛药。

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The N-type calcium channel rises from the ashes.

Chronic pain is a debilitating condition that affects up to 1.5 billion people globally. Advancing pain management depends on a thorough understanding of the types of pain experienced by patients and the underlying mechanisms driving it. N-type calcium channels play a crucial role as therapeutic targets for managing chronic pain. In this issue of the JCI, Tang et al. introduce C2230, an N-type calcium channel blocker that inhibited CaV2.2 channels during high frequency stimulation with little effect on other ion channels in the pain pathway across multiple models. C2230 offers a promising analgesic for use in therapeutic intervention.

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来源期刊

Journal of Clinical Investigation 医学-医学：研究与实验

CiteScore

24.50

自引率

1.30%

发文量

1034

审稿时长

2 months

期刊介绍： The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.