{"title":"揭示引发宿主细胞衰老的肠道微生物衍生代谢物。","authors":"","doi":"10.1038/s43587-025-00831-3","DOIUrl":null,"url":null,"abstract":"During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via adrenoreceptor–AMPK signaling. Low-dose adrenoreceptor blockade treatment mitigates this PAGln-induced cellular senescence.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"346-347"},"PeriodicalIF":19.4000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Uncovering a gut microbiota-derived metabolite that triggers host cellular senescence\",\"authors\":\"\",\"doi\":\"10.1038/s43587-025-00831-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via adrenoreceptor–AMPK signaling. Low-dose adrenoreceptor blockade treatment mitigates this PAGln-induced cellular senescence.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 3\",\"pages\":\"346-347\"},\"PeriodicalIF\":19.4000,\"publicationDate\":\"2025-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00831-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00831-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Uncovering a gut microbiota-derived metabolite that triggers host cellular senescence
During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via adrenoreceptor–AMPK signaling. Low-dose adrenoreceptor blockade treatment mitigates this PAGln-induced cellular senescence.
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