Clinical nutrition research Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI:10.7762/cnr.2025.14.1.65
Jin Gyeom Kim, Jiye Park, Sooyeon Baek, Seunghyun Won, Jin Cho
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摘要

肥胖是一个重大的全球健康问题,它不仅会增加代谢紊乱的风险,还会影响心理健康,尤其是由于荷尔蒙波动和社会压力而影响女性。本研究调查了柠檬香脂(Melissa officinalis)提取物对以高脂饮食(HFD)喂养的雌性 C57BL/6 小鼠(n = 16,17 周大)的抗肥胖和抗焦虑作用。我们比较了两种提取物方法:蒸馏水(LBD,n = 5)和 80% 乙醇(LBE,n = 6)。与对照组(n = 5)相比,两组提取物在实验期间的体重增加率均较低(LBD:27.74%,LBE:29.71% vs. 对照组:51.88%,p < 0.05)。在所检测的脂肪组织(mWAT 和肠系膜旁白色脂肪组织 [pWAT])中,提取物能明显减少肠系膜白色脂肪组织(mWAT)。虽然枸杞多糖和枸杞乙素都能降低pWAT中脂肪酸合成酶(FAS)mRNA的表达,但只有枸杞多糖能降低mWAT中过氧化物酶体增殖激活受体γ和FAS mRNA的表达。在高架加迷宫行为实验中,枸杞多糖组减少了焦虑样行为,与其他组相比,枸杞多糖组在开放臂中花费的时间明显更长,行进的距离更远(p < 0.05),这与脑部炎症标志物无关。我们的研究结果表明,柠檬香脂提取物可同时解决雌性小鼠的肥胖和焦虑行为问题,其功效和作用机制随提取溶剂的变化而变化。这些结果表明,柠檬香膏作为一种功能性食品配料具有潜在的治疗用途,特别是对同时出现肥胖和焦虑症状的女性。
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Effects of Melissa officinalis Extracts on Obesity and Anxiety.

Obesity is a significant global health concern that not only increases metabolic disorders risks but also impacts mental health, particularly affecting women due to hormonal fluctuations and societal pressures. This study investigated anti-obesity and anti-anxiety effects of lemon balm (Melissa officinalis) extracts in female C57BL/6 mouse (n = 16, 17 weeks old) fed a high-fat diet (HFD). We compared 2 extracts method: distilled water (LBD, n = 5) and 80% ethanol (LBE, n = 6), administered via oral gavage (200 mg/kg/day) for 6 weeks alongside HFD. Both extract groups showed lower weight increase ratio compared to the control group in experiment period (n = 5) (LBD: 27.74%, LBE: 29.71% vs. Control: 51.88%, p < 0.05). The extracts significantly decreased mesenteric white adipose tissue (mWAT) among WATs examined (mWAT and parametrial white adipose tissue [pWAT]). While both LBD and LBE reduced fatty acid synthase (FAS) mRNA expression in pWAT, only LBD reduced peroxisome proliferator-activated receptor gamma and FAS mRNA expression in mWAT. In elevated plus maze behavioral experiments, the LBD group displayed reduced anxiety-like behavior, spending significantly more time and travelling greater distances in the open arms compared to other groups (p < 0.05), independent of brain inflammatory markers. Our findings demonstrate lemon balm extracts simultaneously address both obesity and anxiety-like behaviors in female mice, with extraction solvent-dependent variations in efficacy and mechanism of action. These results suggest potential therapeutic applications for lemon balm as a functional food ingredient, particularly for women experiencing concurrent obesity and anxiety symptoms.

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