工程脂肪细胞用于癌症治疗

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nature Reviews Endocrinology Pub Date : 2025-02-20 DOI:10.1038/s41574-025-01095-y
Claire Greenhill
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引用次数: 0

摘要

众所周知,肿瘤细胞具有改变的代谢特征,比周围细胞更能获得和代谢营养物质。现有的几种癌症疗法针对肿瘤代谢。《自然生物技术》上的一项新研究报告了一种基于细胞的疗法的发展,该疗法使用工程脂肪细胞通过改变肿瘤代谢来减少肿瘤细胞的生长。研究人员使用CRISPR激活来上调脂肪细胞中的UCP1、PPARGC1A或PRDM16,导致褐变并增加葡萄糖和脂质代谢。然后将这些工程脂肪细胞与乳腺癌、胰腺癌、结肠癌或前列腺癌细胞系共培养,抑制癌细胞增殖,减少癌细胞中的葡萄糖摄取、糖酵解和脂肪酸氧化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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