{"title":"镍催化芳香羧酸与P(O)-H(2)化合物脱羰基化形成C-P键。","authors":"Jia-Xin Li, Rui Tian, Yong-Ming Zhu","doi":"10.1021/acs.joc.4c02554","DOIUrl":null,"url":null,"abstract":"<p><p>A novel strategy for C-P bond formation has been developed. The reaction employed aromatic carboxylic acids as the source of aromatic groups to couple with three types of P(O)-H<sub>(2)</sub> compounds without the need to isolate intermediates, thereby achieving a one-pot construction of carbon-phosphorus bonds. The protocol demonstrated excellent applicability and functional group tolerance, enabling the production of Ar-P(O)R<sub>2</sub> and Ar<sub>2</sub>-PPh with moderate to excellent yields.</p>","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":" ","pages":"3184-3193"},"PeriodicalIF":3.6000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nickel-Catalyzed Decarbonylation of Aromatic Carboxylic Acids with P(O)-H<sub>(2)</sub> Compounds to Form C-P Bonds.\",\"authors\":\"Jia-Xin Li, Rui Tian, Yong-Ming Zhu\",\"doi\":\"10.1021/acs.joc.4c02554\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A novel strategy for C-P bond formation has been developed. The reaction employed aromatic carboxylic acids as the source of aromatic groups to couple with three types of P(O)-H<sub>(2)</sub> compounds without the need to isolate intermediates, thereby achieving a one-pot construction of carbon-phosphorus bonds. The protocol demonstrated excellent applicability and functional group tolerance, enabling the production of Ar-P(O)R<sub>2</sub> and Ar<sub>2</sub>-PPh with moderate to excellent yields.</p>\",\"PeriodicalId\":57,\"journal\":{\"name\":\"Journal of Organic Chemistry\",\"volume\":\" \",\"pages\":\"3184-3193\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Organic Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.joc.4c02554\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.4c02554","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Nickel-Catalyzed Decarbonylation of Aromatic Carboxylic Acids with P(O)-H(2) Compounds to Form C-P Bonds.
A novel strategy for C-P bond formation has been developed. The reaction employed aromatic carboxylic acids as the source of aromatic groups to couple with three types of P(O)-H(2) compounds without the need to isolate intermediates, thereby achieving a one-pot construction of carbon-phosphorus bonds. The protocol demonstrated excellent applicability and functional group tolerance, enabling the production of Ar-P(O)R2 and Ar2-PPh with moderate to excellent yields.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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