不对称合成无保护色氨酸衍生物的禾草胺通过Ni（II）配合物

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC Journal of Organic Chemistry Pub Date : 2025-02-21 DOI:10.1021/acs.joc.4c02406

Zhekai Xiao, Yazhou Li, Yuzhu Wu, Qiangqiang Chen, Shengbin Zhou, Vadim A. Soloshonok, Jiang Wang, Hong Liu

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引用次数: 0

摘要

本文报道了用甘氨酸和谷氨酸的Ni（II）配合物合成取代色氨酸。该反应在操作方便和温和的条件下进行，使用廉价、无毒和容易获得的试剂。该反应具有产率高和几乎完全的热力学控制非对映选择性的特点，为合成定制色氨酸提供了方便的方法。

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Asymmetric Synthesis of Unprotected Tryptophan Derivatives Using Gramines via Ni(II) Complexes

We herein report the synthesis of substituted tryptophans using Ni(II) complexes of glycine and gramines. This reaction proceeds under operationally convenient and mild conditions, using inexpensive, nontoxic, and easily accessible reagents. The reactions feature high yields and virtually complete thermodynamically controlled diastereoselectivity, providing a convenient method for the synthesis of tailor-made tryptophans.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.