Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI:10.1055/a-2376-0783
Laura Katharina Sievers, Roland Schmitt
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摘要

肾脏疾病的病理生理学常常意味着无菌性炎症,例如肾小球肾炎或肾移植后。最近,全身性低度炎症与慢性肾脏病(CKD)进展和并发症的相关性开始受到关注。这篇综述文章讨论了慢性肾脏病患者低度炎症的病因和后果。此外,文章还探讨了抗炎方法在减缓慢性肾脏病进展方面的潜力。最近,美国食品及药物管理局(FDA)批准将秋水仙碱用于肾功能保留和动脉粥样硬化患者。总之,抗炎疗法为改善 CKD 的进展、抑制急性肾病向慢性肾病的转变以及降低致命的长期并发症(如心血管疾病)的风险提供了新的机会。
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[Anti-inflammatory therapeutic advances in nephrology: can we learn from cardiology?]

Pathophysiology of kidney diseases frequently implies sterile inflammation, e.g. during glomerulonephritis or after renal transplantation. Recently, the relevance of systemic low-grade inflammation for chronic kidney disease (CKD) progression and complications of CKD have come into focus. In this review article, the etiology, and consequences of low-grade inflammation in CKD patients are discussed. Further, the potential of anti-inflammatory approaches to slow down CKD progression is addressed. Recent advances have resulted in FDA approval of colchicine for patients with preserved renal function and atherosclerosis. Thus, lastly, anti-inflammatory therapy of atherosclerosis in patients with or without CKD is outlined.Taken together, anti-inflammatory therapy offers novel opportunities to improve CKD progression, inhibit transition from acute to chronic kidney disease and reduce the risk of fatal long-term complications such as cardiovascular disease.

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[Unstable heart failure: practical guidelines for avoiding frequent hospital admissions]. [89-year-old patient with epigastric pain and hematin vomiting]. [Anti-inflammatory therapeutic advances in nephrology: can we learn from cardiology?] [Celiac disease: Novel pharmacological therapies]. [Endometrial cancer].
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