Adam Jr Watson, Ryan Riordan, Julian Hannah, Tim Nicholson Roberts, James Plumb
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引用次数: 0
摘要
高渗盐水（HTS）可能具有抗炎特性。我们的目的是研究院前HTS对严重创伤性脑损伤（tbi）患者中性粒细胞与淋巴细胞比率（NLR）的影响，NLR是一种简单的系统性炎症指标。我们纳入了110例需要院前麻醉的钝性脑损伤患者（中位年龄57.1岁，67%为男性）。入院时，接受院前HTS的患者NLR中位数较低（7.9 vs 11.9, p = 0.021），在多变量分析中，HTS使用仍与NLR相关（p = 0.048）。我们相信我们的发现强调了HTS的神经炎症特性是未来研究的一个领域。
Effect of pre-hospital hypertonic saline on neutrophil to lymphocyte ratio in traumatic brain injury: A retrospective analysis.
Hypertonic saline (HTS) may have anti-inflammatory properties. We aimed to investigate the effect of pre-hospital HTS on neutrophil to lymphocyte ratio (NLR), a simple marker of systematic inflammation, in patients with severe traumatic brain injury (TBIs). We included 110 adults with blunt TBIs requiring pre-hospital anaesthesia (median age 57.1 years, 67% male). On hospital admission, median NLR was lower in patients who received pre-hospital HTS (7.9 vs 11.9, p = 0.021), and in multivariable analysis, HTS use remained associated with NLR (p = 0.048). We believe our findings highlight the neuroinflammatory properties of HTS as an area for future research.
期刊介绍：
The Journal of the Intensive Care Society (JICS) is an international, peer-reviewed journal that strives to disseminate clinically and scientifically relevant peer-reviewed research, evaluation, experience and opinion to all staff working in the field of intensive care medicine. Our aim is to inform clinicians on the provision of best practice and provide direction for innovative scientific research in what is one of the broadest and most multi-disciplinary healthcare specialties. While original articles and systematic reviews lie at the heart of the Journal, we also value and recognise the need for opinion articles, case reports and correspondence to guide clinically and scientifically important areas in which conclusive evidence is lacking. The style of the Journal is based on its founding mission statement to ‘instruct, inform and entertain by encompassing the best aspects of both tabloid and broadsheet''.
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