功能化希夫碱金属配合物的DNA结合活性

IF 2 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR European Journal of Inorganic Chemistry Pub Date : 2025-01-30 DOI:10.1002/ejic.202400705

Luisa D'Anna, Laura Marretta, Aurane Froux, Simona Rubino, Valeria Butera, Angelo Spinello, Riccardo Bonsignore, Alessio Terenzi, Giampaolo Barone

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摘要

基于我们最近的研究经验，本文综述了salen， salphen和salnaphen金属配合物的DNA结合，重点介绍了在特殊基因组区域和癌症调控中至关重要的g -四重体（G4） DNA。事实上，这种金属配合物已经显示出显著的结合和稳定G4结构的能力。我们将指出金属中心和配体取代基的作用影响它们对G4s的结合和选择性，并通过实验和计算研究来支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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DNA Binding Activity of Functionalized Schiff Base Metal Complexes

Based on our recent research experience, this review highlights the DNA binding of salen, salphen and salnaphen metal complexes, with a focus on G-quadruplex (G4) DNA, which is crucial in peculiar genomic regions and in cancer regulation. Such metal complexes have in fact shown significant ability to bind and stabilize G4 structures. We will point out the role of the metal center and of the ligand substituents affecting their binding and selectivity toward G4s, supported by experimental and computational studies.

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来源期刊

European Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

4.30

自引率

4.30%

发文量

419

审稿时长

1.3 months

期刊介绍： The European Journal of Inorganic Chemistry (2019 ISI Impact Factor: 2.529) publishes Full Papers, Communications, and Minireviews from the entire spectrum of inorganic, organometallic, bioinorganic, and solid-state chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form the two leading journals, European Journal of Inorganic Chemistry and European Journal of Organic Chemistry: Chemische Berichte Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry The European Journal of Inorganic Chemistry continues to keep you up-to-date with important inorganic chemistry research results.