Functional neuroimaging in disorders of consciousness: towards clinical implementation.

Functional neuroimaging has provided several new tools for improving both the diagnosis and prognosis in patients with disorders of consciousness. These tools are now being used to detect residual and covert awareness in behaviourally non-responsive patients with an acquired severe brain injury and predict which patients are likely to recover. Despite endorsement of advanced imaging by multiple clinical bodies, widespread implementation of imaging techniques such as functional MRI (fMRI), EEG and PET in both acute and prolonged disorders of consciousness patients has been hindered by perceived costs, technological barriers, and lack of expertise needed to acquire, interpret and implement these methods. In this review we provide a comprehensive overview of neuroimaging in disorders of consciousness, the different technical approaches employed (i.e. fMRI, EEG, PET), the imaging paradigms used (active, passive, resting state) and the types of inferences that have been made about residual cortical function based on those paradigms (e.g. perception, awareness, communication). Next, we outline how these barriers might be overcome, discuss which select patients stand to benefit the most from these neuroimaging techniques, and consider when, during their clinical trajectory, imaging tests are likely to be most useful. Moreover, we make recommendations that will help clinicians decide which advanced imaging technologies and protocols are likely to be most appropriate in any particular clinical case. Finally, we describe how these techniques can be implemented in routine clinical care to augment current clinical tools and outline future directions for the field as a whole.