早期非小细胞肺癌精确免疫治疗路线图

IF 33.3 1区 医学 Q1 ONCOLOGY Cancer discovery Pub Date : 2025-05-02 DOI:10.1158/2159-8290.CD-25-0262
Alessandra Vaccaro, Zahraa Rahal, Humam Kadara, Tina Cascone
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引用次数: 0

摘要

免疫疗法已经彻底改变了早期非小细胞肺癌的治疗;然而,许多患者未能获得长期的益处,部分原因是生物标志物预测不完整或不一致。综合多组学,结合肿瘤内在、免疫微环境和全身因素,为精确免疫治疗提供了更全面的框架,使患者分层、治疗选择和结果得到改善。
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A Roadmap to Precision Immunotherapy for Early-Stage Non-Small Cell Lung Cancer.

Immunotherapy has revolutionized the treatment of early-stage non-small cell lung cancer; yet many patients fail to achieve long-lasting benefit, partially because of incomplete or inconsistent biomarker predictions. Integrative multiomics, combining tumor-intrinsic, immune microenvironment, and systemic factors, offer a more comprehensive framework for precision immunotherapy, enabling improved patient stratification, treatment selection and outcomes.

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来源期刊
Cancer discovery
Cancer discovery ONCOLOGY-
CiteScore
22.90
自引率
1.40%
发文量
838
审稿时长
6-12 weeks
期刊介绍: Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.
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