The Early Exposure Rate and Vertical Bone Gain of Titanium Mesh for Maxillary Bone Regeneration: A Systematic Review and Meta-Analysis.

Background/Objectives: The use of titanium meshes in bone regeneration is a clinical procedure that regenerates bone defects by ensuring graft stability and biocompatibility. The aim of the present investigation was to evaluate the clinical effectiveness of titanium mesh procedures in terms of vertical bone gain and the exposure rate. Methods: The product screening and eligibility analysis were performed using the Pubmed/MEDLINE, EMBASE, and Google Scholar electronic databases by two authors. The selected articles were classified based on the study design, regenerative technique, tested groups and materials, sample size, clinical findings, and follow-up. A risk of bias calculation was conducted on the selected randomized controlled trials (RCTs) and non-randomized trials and a series of pairwise meta-analysis calculations were performed for the vertical bone gain (VBG) and exposure rate. A significantly lower exposure rate was observed using coronally advanced lingual flaps (p < 0.05). No difference was observed between the titanium mesh and GBR techniques in terms of VBG (p > 0.05). Results: The initial search output 288 articles, and 164 papers were excluded after the eligibility analysis. The descriptive synthesis considered a total of 97 papers and 6 articles were considered for the pairwise comparison. Conclusions: Within the limits of the present investigation, the titanium mesh procedure reported high VBG values after the healing period. The mesh exposure rate was drastically lower with passive management of the surgical flap.