在腰椎磁共振成像中探讨脂肪分数和椎体骨质量评分：相关性和临床意义的横断面研究。

IF 3.8 3区医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2025-02-19 DOI:10.3390/diagnostics15040503

Sunghoon Park, Jinwoo Hwang, Kyu-Sung Kwack, Kyu Hong Lee, Jae Sung Yun

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引用次数: 0

摘要

背景/目的：虽然基于梯度回波（GRE）的化学位移编码磁共振成像（CSE-MRI）为测量骨髓脂肪提供了精确的方法，但其局限性在于需要额外的成像。另一方面，基于自旋回波（SE）的CSE-MRI可以无缝地集成到传统方案中。最近，一种名为椎体骨质量（VBQ）评分的新技术被引入。本研究的目的是探讨基于gre的CSE-MRI （FFGRE）测量的脂肪分数（FF）与基于se的CSE-MRI （FFSE）测量的FF或VBQ评分之间的关系。方法：对344例患者进行回顾性研究，采用Pearson相关系数(r)评估FFGRE与VBQ评分的相关性以及各指标与年龄的相关性，采用Lin’s一致性相关系数（ρc）评估FFGRE与FFSE的一致性。将41例椎体病变分为良性和恶性，采用Mann-Whitney U检验进行比较。结果：FFGRE与FFSE、VBQ评分呈显著正相关（r分别为0.861、0.708）。而FFGRE与FFSE的一致性较差（ρc = 0.295）。所有指标均与年龄有中等相关性(FFGRE, r = 0.583；FFSE, r = 0.477；VBQ评分，r = 0.468)。FF在良性病变中显著升高(FFGRE, p = 0.004；FFSE, p = 0.007)，而VBQ评分两组间差异无统计学意义（p = 0.089）。结论：FFGRE与VBQ评分有较高的相关性。FFSE与FFGRE有很强的相关性，但用FFSE代替FFGRE可能具有挑战性。FF和VBQ得分均与年龄适度相关。良性和恶性病变之间的FF表现出统计学上的显著差异，而VBQ评分没有提供可区分的分离。

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Exploring Fat Fraction and Vertebral Bone Quality Score in Lumbar Spine Magnetic Resonance Imaging: A Cross-Sectional Study on Associations and Clinical Implication.

Background/Objectives: While gradient-echo (GRE)-based chemical shift-encoded magnetic resonance imaging (CSE-MRI) offers precise method for measuring adiposity in bone marrow, its limitation lies in the need for additional imaging. On the other hand, spin-echo (SE)-based CSE-MRI can seamlessly integrate into conventional protocols. Recently, a novel technique called the vertebral bone quality (VBQ) score has been introduced. The objective of this study was to investigate the association between fat fraction (FF) measured by GRE-based CSE-MRI (FF_GRE) and FF measured by SE-based CSE-MRI (FF_SE) or the VBQ score. Methods: A retrospective study with 344 patients assessed the correlation between FF and the VBQ score and each measurement's correlation with age using Pearson's correlation (r). Concordance between FF_GRE and FF_SE was assessed using Lin's concordance correlation coefficient (ρ_c). Vertebral lesions (n = 41) were categorized as benign and malignant, and the Mann-Whitney U test was used for comparison. Results: FF_GRE demonstrated strong positive correlations with FF_SE and the VBQ score (r = 0.861 and 0.708, respectively). However, the concordance between FF_GRE and FF_SE was poor (ρ_c = 0.295). All measurements moderately correlated with age (FF_GRE, r = 0.583; FF_SE, r = 0.477; VBQ score, r = 0.468). FF was significantly higher in benign lesions (FF_GRE, p = 0.004; FF_SE, p = 0.007), while the VBQ score did not show statistically significant differences between the two groups (p = 0.089). Conclusions: FF_GRE exhibited a high correlation with the VBQ score. FF_SE showed a strong correlation with FF_GRE, but replacing FF_GRE with FF_SE may be challenging. Both FF and the VBQ score moderately correlated with age. FF demonstrated statistically significant differences between benign and malignant lesions, while the VBQ score did not provide a distinguishable separation.

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来源期刊

Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

4.70

自引率

8.30%

发文量

2699

审稿时长

19.64 days

期刊介绍： Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.