妊娠期巨细胞病毒感染中的血管生成标志物PlGF和sFlt-1：来自一个临床病例的见解。

IF 3.8 3区医学 Q2 VIROLOGY Viruses-Basel Pub Date : 2025-02-15 DOI:10.3390/v17020267

Valentina Giardini, Ramona Chiozzi, Federica Fernicola, Marco Casati, Anna Locatelli, Sara Ornaghi

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摘要

巨细胞病毒（CMV）感染在怀孕期间是先天性感染的主要原因，随后病毒经胎盘传播。巨细胞病毒胎盘感染可能通过胎盘功能障碍导致不良后果的发生。本病例报告显示了血管生成标志物，如胎盘生长因子（PlGF）和可溶性膜样酪氨酸激酶-1 (sFlt-1)，在评估巨细胞病毒相关的胎盘累及和监测抗病毒治疗对胎盘功能的影响方面的潜在效用，并强调了将这些标志物整合到巨细胞病毒感染的临床管理中的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Angiogenic Markers PlGF and sFlt-1 in Cytomegalovirus Infection During Pregnancy: Insights from a Clinical Case.

Cytomegalovirus (CMV) infection during pregnancy is the leading cause of congenital infection subsequent to viral transplacental transmission. CMV placental infection can contribute to the development of adverse outcomes likely through placental dysfunction. This case report shows the potential utility of angiogenic markers, such as placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1), in assessing CMV-related placental involvement and monitoring the effect of antiviral therapy on placental function, and highlights the possibility of integrating these markers into the clinical management of CMV infection.

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.