用小分子工具探测癌症——进展与挑战

IF 56.1 1区医学 Q1 CELL BIOLOGY Cancer Cell Pub Date : 2025-02-27 DOI:10.1016/j.ccell.2025.02.003

Susanne Müller, Domenico Sanfelice, Paul Workman

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引用次数: 0

摘要

化学探针是基础和转化癌症研究中强大的小分子工具。它们是高度通用的，在蛋白质功能的注释中补充了基因技术，在靶标验证和药物发现方面是无价的。然而，在选择和使用化学探针方面，需要不断改进以加强最佳实践。我们讨论了过去十年的进展，强调了关键问题，并指出了为每种人类蛋白质生成高质量化学探针的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Probing cancer with small-molecule tools—Progress and challenges

Chemical probes are powerful small-molecule tools in fundamental and translational cancer research. They are highly versatile, complementing genetic technologies in the annotation of protein function, and invaluable in target validation and drug discovery. However, continued improvements are needed to enhance best practices in selection and use of chemical probes. We discuss progress over the last decade, highlight key issues, and indicate a path to generate a high-quality chemical probe for every human protein.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.