An overview of recent advances in enantioselective multicomponent reactions

Sequential transformations of three or more substrates in multicomponent reactions are known to yield architecturally intricate products. A vast majority of substrate components are transformed into the intended products with minimal generation of byproducts. The efficiency and variety of these reactions have led to their prominence in synthetic organic chemistry. Recently, the importance of enantioselective multicomponent processes has grown, especially in the domain of pharmaceutical and biological molecule synthesis, due to the unique biological properties displayed by enantiomers and diastereomers. The objective of the present review article is to provide an overview of the progress made in the enantioselective synthesis of compounds using multicomponent reactions, focusing on recent publications.