小鼠对全身奎尼丁的光过敏:剂量反应研究。

Photo-dermatology Pub Date : 1988-10-01
L E Wirestrand, B Ljunggren
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引用次数: 0

摘要

奎尼丁与UVB和UVA联合全身给药后,引起小鼠光过敏性皮炎。反应记录为穗湿重、穗厚和尾湿重。统计计算表明,耳湿重是最灵敏的评价方法。通过改变诱导剂量(2.5 ~ 100 mg/kg)和激发剂量(10 ~ 100 mg/kg),建立了剂量-反应条件。结果表明,获得统计显著性反应所需的诱导剂量远低于最小激发剂量(25 mg/kg)。这种方法非常适合于研究系统诱导的光过敏的诱导和激发阶段的动力学。
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Photoallergy to systemic quinidine in the mouse: dose-response studies.

Photoallergic dermatitis was induced in the mouse following the systemic administration of quinidine in combination with UVB and UVA. The reaction was recorded as ear wet weight, ear thickness and tail wet weight. Statistical calculations showed ear wet weight to be the most sensitive evaluation technique. By varying the quinidine dose administered in induction (2.5-100 mg/kg) and challenge (10-100 mg/kg), dose-response conditions were established. It was shown that the induction dose necessary to obtain a statistically significant reaction was considerably lower than the minimal challenge dose (25 mg/kg). This method is well suited for studies of the dynamics of the induction and elicitation phases of systemically induced photoallergy.

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