可见光诱导EDA配合物促进五氟苯乙烯脱胺烷基化反应

IF 2 3区化学 Q3 CHEMISTRY, ORGANIC Synthetic Communications Pub Date : 2025-03-19 Epub Date: 2025-02-12 DOI:10.1080/00397911.2025.2462668

Bei-Lei Wang , Lin-Yuan Zeng , Pei-Zhen Qu , De-Zhi Yang

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引用次数: 0

摘要

多氟芳香族化合物是医药和材料科学中的重要成分，然而合成烷基化五氟苯乙烯的方法仍然有限。在此，我们开发了一种卡氏盐与五氟苯乙烯的脱氨基偶联反应，在电子供体-受体（EDA）复合物的光化学活性的促进下构建 C6F5-C（sp3）键。该方法具有反应条件简单、底物范围广、官能团耐受性好等特点。

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Visible light induced deaminative alkylation of pentafluorostyrene promoted by EDA complex

Polyfluoroaromatic compounds are important components in medicinal and material science, however, methodologies for the synthesis of alkylated pentafluoroarenes remains limited. Here we developed a deaminative coupling reaction of Katritzky salts with pentafluorostyrene to construct C₆F₅-C(sp³) bonds promoted by the photochemical activity of electron donor-acceptor (EDA) complexes. This method features simple reaction conditions, a broad substrate scope, and good functional group tolerance.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.