糖尿病和HbA1c作为COVID-19住院患者死亡率的预测因子

IF 2.8 Q3 ENDOCRINOLOGY & METABOLISM Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI:10.1080/17446651.2025.2469627

Praveen Gupta, Sandeep Bansal, Ira Balakrishnan, Anunay Gupta

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引用次数: 0

摘要

背景：糖尿病（DM）在住院COVID-19患者中的作用以及HbA1c在住院COVID-19合并DM患者中的作用以往研究不足。研究设计与方法：回顾性队列研究。本研究分析了305例住院COVID-19患者的数据。研究目的是确定糖尿病与COVID-19患者住院死亡率的关系。另一个研究目的是确定HbA1c与COVID-19合并糖尿病患者死亡率的关系。结果：在这项回顾性研究中，41.3%（126/305）的研究人群存在糖尿病。多因素Cox回归分析显示，糖尿病与死亡率之间存在显著相关性（校正风险比（aHR）： 2.116, 95% CI: 1.088-4.116, p = 0.027）。糖尿病患者的中位HbA1c为8.9%（7.5-11.0）。多因素cox-回归分析发现HbA1c与糖尿病患者的死亡率相关（aHR:1.272, 95% CI: 1.028-1.574, p = 0.027）。多因素Cox回归分析还显示，HbA1c（10.5%≤HbA1c > 10.5%）作为二分类变量与糖尿病患者住院死亡率相关（aHR: 2.53, 95% CI: 2.606 ~ 194.81, p = 0.005）。结论：在多因素分析中，DM与COVID-19住院患者的死亡率独立相关。在合并DM的COVID-19患者中，在多变量分析中，HbA1c作为一个连续的二分变量与死亡率相关。

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Diabetes mellitus and HbA1c as predictors of mortality in hospitalized COVID-19 patients.

Background: The role of diabetes mellitus (DM) in hospitalized COVID-19 patients and of HbA1c in hospitalized COVID-19 patients with DM were not studied adequately in the past.

Research design and methods: It was a retrospective cohort study. In this study, data from 305 hospitalized COVID-19 patients was analyzed. The study objective was to determine the association of DM with in-hospital mortality in COVID-19 patients. Another study objective was to determine the association of HbA1c with mortality in COVID-19 patients with DM.

Results: In this retrospective study, DM was present in 41.3% (126/305) of the study population. The multivariate Cox regression analysis showed a significant association between DM and mortality (adjusted hazard ratio (aHR): 2.116, 95% CI: 1.088-4.116, p = 0.027). The median HbA1c in diabetic patients was 8.9% (7.5-11.0). HbA1c was found to be associated with mortality in diabetic patients in the multivariate cox-regression analysis (aHR:1.272, 95% CI: 1.028-1.574, p = 0.027). The multivariate Cox regression analysis also showed the association of HbA1c (10.5%≤HbA1c > 10.5%) as a dichotomous variable with in-hospital mortality (aHR: 2.53, 95% CI: 2.606-194.81, p = 0.005) in diabetic patients.

Conclusions: DM was independently associated with mortality in hospitalized COVID-19 patients in the multivariate analysis. In COVID-19 patients with DM, HbA1c was associated with mortality as a continuous and dichotomous variable in the multivariate analysis.

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Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

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4.80

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期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.

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