钯催化邻碳硼烷与CO和醇的选择性B(3)-酯化反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-03-03 DOI:10.1021/acs.orglett.5c00308

Shuai Zhu, Yizhen Liu, Zuowei Xie

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引用次数: 0

摘要

邻碳硼烷的选择性官能化，特别是邻碳硼烷笼中十个化学性质相似的 BH 顶点的区域选择性修饰，受到了极大的关注。我们在此公开了一种以六羰基钨为一氧化碳源，在钯催化下对邻碳硼烷中的 B(3)-H 键进行酯化的策略。相应的官能化邻硼烷以中等到非常好的收率制备出来，并具有极佳的区域选择性。

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Palladium-Catalyzed Selective B(3)-Esterification of o-Carboranes with CO and Alcohols

Selective functionalization of o-carboranes has received tremendous attention, specifically in the regioselective modification of the ten chemically similar BH vertices within o-carborane cage. We disclose herein a strategy for palladium-catalyzed esterification of the B(3)–H bond in o-carboranes using tungsten hexacarbonyl as a carbon monoxide source. The corresponding functionalized o-carboranes were prepared in moderate to very good yields with excellent regioselectivity.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.