Synthesis and Voltammetric Studies Concerning a Phenyl Trisilanol Polyhedral Oligosilsesquioxane Modified with Phosphate and Methylene Blue for Pyridoxine Detection

This study describes the synthesis of a phenyl trisilanol polyhedral oligosilsesquioxane (POSS) employing calcium and its subsequent modification by phosphate and methylene blue for electrochemical applications. Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, and scanning electron microscopy, were employed to characterize the developed material. The obtained POSS was characterized by cyclic coltammetry employing a graphite paste electrode, exhibiting well-defined redox pairs. The modified graphite paste electrode demonstrated an adequate electrocatalytic response for pyridoxine. Regarding catalytic pyridoxine electro-oxidation, the modified electrode exhibited a linear response ranging from 7.0 × 10⁻⁶ to 1.0 × 10⁻³ mol L⁻¹, with a limit of detection of 3.24 × 10⁻⁶ mol L⁻¹. The studied material, therefore, comprises a potential candidate for the development of electrochemical sensors for pyridoxine detection.