亚麻、椰子、葵花籽和橄榄油混合食用油在健康大鼠体内的生物安全性评价

IF 6.2 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of Agriculture and Food Research Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI:10.1016/j.jafr.2025.101768

Roshina Rabail , Abdur Rauf Khalid , Amin Mousavi Khaneghah , Muhammad Faisal Manzoor , Gholamreza Abdi , Rana Muhammad Aadil

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引用次数: 0

摘要

食用油混合形成一种保护健康的脂肪酸组合，为食品科学打开了新的大门。材料与方法本研究在健康大鼠身上对椰子油（CO）、亚麻籽油（FO）、特级初榨橄榄油（EVOO）和葵花籽油（SFO）制成的混合油（BO）进行了为期42天的生物安全性评价。大鼠被给予这些油作为100%脂肪替代品作为对照。结果与单一油脂相比，薄荷叶精油可显著降低大鼠体增重（68.8±10.84）、BMI（0.128±0.01）、体脂含量（- 0.41±3.41）、总胆固醇（43.00±7.84）、甘油三酯（90.00±9.00）、总脂质含量（176.00±24.39）、低密度脂蛋白（14.00±4.12），显著改善HDL、LFTs、RFTs和血液学指标。BO消费对心血管危险指标也有最大保护作用，包括动脉粥样硬化（0.99±0.16）和冠状动脉（3.07±0.21）指标。心电图结果也显示心波节律正常。结论经常食用其可减少肥胖和代谢性疾病的发生。

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Biosafety assessment of edible oil blended from flax, coconut, sunflower, and olive oils in healthy Sprague Dawley rats

Edible oil blending to formulate a health-protective fatty acid combination has opened new doors in food science.

Material and methods

In this study, a 42-day biosafety assessment of a blended oil (BO) made from oils of coconut (CO), flaxseed (FO), extra virgin olive (EVOO), and sunflower (SFO) was performed on healthy rats. Rats were given these oils as 100 % fat replacement in control.

Results

The results of BO in rats encouraged its health protection properties by significantly lowering body weight gain (68.8 ± 10.84), BMI (0.128 ± 0.01), body fat content (−0.41 ± 3.41), total cholesterol (43.00 ± 7.84), triglycerides (90.00 ± 9.00), total lipid contents (176.00 ± 24.39), and LDL (14.00 ± 4.12) while substantially improving HDL, LFTs, RFTs, and hematology when compared to single oils. BO consumption also indicated maximum protection against cardiovascular risk indices, including atherogenic (0.99 ± 0.16) and coronary (3.07 ± 0.21) indexes. Results for ECG also showed a normal cardiac rhythm in cardiac waves.