Hugo Wf Mak, Weihong Shi, Erin Hc Shum, Jackie Sh Yim, Elaine Lee, Dorothy Ly Lam, Philip H Li
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From Statistical to Clinical Significance: Establishing and Testing the Minimal Clinically Important Difference of the Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q).
Clinical implications: We propose 6.3 (small effect), 12.5 (medium effect), and 18.8 (large effect) as the DrHy-Q6's minimal clinically important difference. Drug hypersensitivity reactions delabelling significantly and progressively improves most patients' health-related quality of life.
期刊介绍:
JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases.
This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders.
The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.