钯催化（杂）芳基氟硫酸盐的Sonogashira交叉偶联

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-03-04 DOI:10.1021/acs.orglett.5c00419

Kathleen M. Morrison, Giulio Volpin, Sherif J. Kaldas, Philipp M. Holstein, Maximilian Lübbesmeyer, Mark James Ford, Nicolas Guimond, Mark Stradiotto

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引用次数: 0

摘要

本文报道了钯催化的（杂）芳基氟磺酸盐与末端炔的Sonogashira交叉偶联反应，该反应具有广泛的合成用途和产率。使用DPPF/[Pd（肉桂基）Cl]2催化剂体系，不需要铜添加剂，就可以实现涉及多种（杂）芳基氟硫酸盐偶联伙伴的转化，包括存在竞争氯官能团的化学选择实例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Palladium-Catalyzed Sonogashira Cross-Couplings of (Hetero)Aryl Fluorosulfates

The palladium-catalyzed Sonogashira cross-coupling of (hetero)aryl fluorosulfates and terminal alkynes, featuring a synthetically useful scope and yields, is reported herein. Such transformations involving a diversity of (hetero)aryl fluorosulfate coupling partners, including chemoselective examples where contending chloro functionalities are present, are achieved using a DPPF/[Pd(cinnamyl)Cl]₂ catalyst system without the requirement of a copper additive.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.