具有大空间位阻的新型NHC-Pd配合物：杂芳基-杂芳基Buchwald-Hartwig胺化反应的合成及其催化活性

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC Tetrahedron Pub Date : 2025-03-01 DOI:10.1016/j.tet.2025.134567

Xian-Fei Deng, Yan-Jun Chen, Li-Yu Yi, Ju Huang

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引用次数: 0

摘要

合成了新的n -杂环碳（NHC）钯络合物{[Pd-PEPPSI-IPrtBuDBB]}，并对其进行了表征。在100℃的好氧条件下，通过n -杂芳胺与芳酰氯的直接C - n芳基化反应来评价钯配合物的催化活性。在最优条件下，2 mol%的大块钯是非常有效的，并能以高收率生产所需的交叉偶联产物。

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New NHC–Pd complexes bearing bulky steric hindrance: Synthesis and catalytic activity in the Heteroaryl–Heteroaryl Buchwald–Hartwig amination reaction

New bulky N-heterocyclic carbene (NHC) palladium complexes {[Pd-PEPPSI-IPr^tBuDBB]} were synthesized and characterized. The catalytic activity of the palladium complexes was evaluated via the direct C–N arylation of N-heteroaryl amines with aryl chlorides in aerobic conditions at 100 °C. Under the optimal conditions, 2 mol% of the bulky palladium was found to be very efficient and produced the desired cross-coupling products in high yields.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.