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IF 6 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Liver International Pub Date : 2025-03-07 DOI:10.1111/liv.70047

Hannele Yki-Järvinen, Panu K. Luukkonen

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摘要

背景和目的与胰岛素抵抗（IR）和代谢综合征（"IR-SLD"）相关的脂肪性肝病（SLD）会增加罹患肝病、2型糖尿病和心血管疾病（CVD）的风险。与 PNPLA3 I148M 变体相关的 SLD（"PNPLA3-SLD"）也易导致肝病，但可预防 2 型糖尿病和心血管疾病。尽管在现实生活中这两种 SLD 病因通常同时存在，但 "IR-SLD "和 "PNPLA3-SLD "对心血管疾病和肝病的影响截然相反，这表明它们的发病机制不同。方法和结果本综述总结了人类数据，比较了 "IR-SLD "和 "PNPLA3-SLD "对人类肝脏脂质组、肝脏处理脂肪酸、肝细胞内甘油三酯合成途径、循环脂质和脂蛋白以及脂肪组织炎症的影响。我们还讨论了 PNPLA3 I148M 携带者的脂肪变性如何导致线粒体功能缺陷。

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Function of PNPLA3 I148M—Lessons From In Vivo Studies in Humans

Background and Aims

Steatotic liver disease (SLD) associated with insulin resistance (IR) and the metabolic syndrome (‘IR-SLD’) increases the risk of liver disease, type 2 diabetes and cardiovascular disease (CVD). SLD associated with the PNPLA3 I148M variant (‘PNPLA3-SLD’) also predisposes individuals to liver disease but protects against type 2 diabetes and CVD. Although in real life the two causes of SLD commonly co-exist, the opposite effects of ‘IR-SLD’ and ‘PNPLA3-SLD’ on CVD and liver disease suggest their pathogenesis differs.

Methods and Results

This review summarises human data comparing the effects of ‘IR-SLD’ and ‘PNPLA3-SLD’ on the human liver lipidome, hepatic handling of fatty acids, pathways of intrahepatocellular triglyceride synthesis, circulating lipids and lipoproteins and adipose tissue inflammation. We also discuss how steatosis in PNPLA3 I148M carriers leads to defects in mitochondrial function.

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来源期刊

Liver International 医学-胃肠肝病学

CiteScore

13.90

自引率

4.50%

发文量

348

审稿时长

2 months

期刊介绍： Liver International promotes all aspects of the science of hepatology from basic research to applied clinical studies. Providing an international forum for the publication of high-quality original research in hepatology, it is an essential resource for everyone working on normal and abnormal structure and function in the liver and its constituent cells, including clinicians and basic scientists involved in the multi-disciplinary field of hepatology. The journal welcomes articles from all fields of hepatology, which may be published as original articles, brief definitive reports, reviews, mini-reviews, images in hepatology and letters to the Editor.