{"title":"表现为强迫症的 CADASIL 综合征:病例报告。","authors":"Derya Canlı, Mesut Keskin","doi":"10.29399/npa.28683","DOIUrl":null,"url":null,"abstract":"<p><p>Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a small vessel disease. It is an autosomal dominant inherited disease caused by a mutation in the Notch3 gene. Clinically, it usually presents with recurrent transient ischemic attacks, strokes, vascular dementia, migraine with aura, cognitive impairments and psychiatric symptoms. Cranial MRI is the most useful imaging modality to demonstrate the characteristic radiological findings of CADASIL and gene analysis is the gold standard for diagnosis. Although the clinical manifestations are mainly neurological, CADASIL can also present with psychiatric disorders. Psychiatric disorders are one of the main clinical manifestations of the disease, with a prevalence rate ranging from 20 to 41%. Among psychiatric disorders, mood disorders are the most commonly reported, and other psychiatric diagnoses include psychotic disorders, anxiety disorders, adjustment disorder, personality disorders, behavioral disorders, substance dependence and abuse. In this case report, a paitent with CADASIL presenting with obsessive-compulsive disorder at a relatively young age will be presented.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 1","pages":"90-93"},"PeriodicalIF":1.0000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877385/pdf/","citationCount":"0","resultStr":"{\"title\":\"CADASIL Syndrome Presenting as Obsessive-Compulsive Disorder: A Case Report.\",\"authors\":\"Derya Canlı, Mesut Keskin\",\"doi\":\"10.29399/npa.28683\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a small vessel disease. It is an autosomal dominant inherited disease caused by a mutation in the Notch3 gene. Clinically, it usually presents with recurrent transient ischemic attacks, strokes, vascular dementia, migraine with aura, cognitive impairments and psychiatric symptoms. Cranial MRI is the most useful imaging modality to demonstrate the characteristic radiological findings of CADASIL and gene analysis is the gold standard for diagnosis. Although the clinical manifestations are mainly neurological, CADASIL can also present with psychiatric disorders. Psychiatric disorders are one of the main clinical manifestations of the disease, with a prevalence rate ranging from 20 to 41%. Among psychiatric disorders, mood disorders are the most commonly reported, and other psychiatric diagnoses include psychotic disorders, anxiety disorders, adjustment disorder, personality disorders, behavioral disorders, substance dependence and abuse. In this case report, a paitent with CADASIL presenting with obsessive-compulsive disorder at a relatively young age will be presented.</p>\",\"PeriodicalId\":51142,\"journal\":{\"name\":\"Noropsikiyatri Arsivi-Archives of Neuropsychiatry\",\"volume\":\"62 1\",\"pages\":\"90-93\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877385/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Noropsikiyatri Arsivi-Archives of Neuropsychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.29399/npa.28683\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.29399/npa.28683","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
CADASIL Syndrome Presenting as Obsessive-Compulsive Disorder: A Case Report.
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a small vessel disease. It is an autosomal dominant inherited disease caused by a mutation in the Notch3 gene. Clinically, it usually presents with recurrent transient ischemic attacks, strokes, vascular dementia, migraine with aura, cognitive impairments and psychiatric symptoms. Cranial MRI is the most useful imaging modality to demonstrate the characteristic radiological findings of CADASIL and gene analysis is the gold standard for diagnosis. Although the clinical manifestations are mainly neurological, CADASIL can also present with psychiatric disorders. Psychiatric disorders are one of the main clinical manifestations of the disease, with a prevalence rate ranging from 20 to 41%. Among psychiatric disorders, mood disorders are the most commonly reported, and other psychiatric diagnoses include psychotic disorders, anxiety disorders, adjustment disorder, personality disorders, behavioral disorders, substance dependence and abuse. In this case report, a paitent with CADASIL presenting with obsessive-compulsive disorder at a relatively young age will be presented.
期刊介绍:
Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume.
Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.