Gianluca Di Pietro , Riccardo Improta , Ovidio De Filippo , Francesco Bruno , Lucia Ilaria Birtolo , Emanuele Bruno , Nicola Galea , Marco Francone , Marc Dewey , Fabrizio D'Ascenzo , Massimo Mancone
{"title":"CCT-FFR作为有症状的稳定型冠状动脉疾病患者第一策略的临床影响：系统回顾和荟萃分析","authors":"Gianluca Di Pietro , Riccardo Improta , Ovidio De Filippo , Francesco Bruno , Lucia Ilaria Birtolo , Emanuele Bruno , Nicola Galea , Marco Francone , Marc Dewey , Fabrizio D'Ascenzo , Massimo Mancone","doi":"10.1016/j.jcct.2025.02.006","DOIUrl":null,"url":null,"abstract":"<div><div>Aims: Despite the promising results, the clinical implications of the CCT-FFR is already debated. This metanalysis aimed to determine the potential benefits of incorporating FFRCT into stable CAD management.</div><div>Methods: After searching for studies comparing outcomes of patients with suspected stable CAD who underwent CCT-FFR as a first strategy versus non-urgent cardiovascular testing after a clinical judgment, we calculated odds ratios (ORs) and 95 % confidence intervals (CIs) using a random-effects or fixed-effects meta-analysis model depending on heterogeneity significance.</div><div>Results: 5 studies (3 RCTs and 2 observational studies) globally encompassing 5282 patients (CCT-FFR = 2604 patients, Control Group = 2678 patients) were included in the quantitative analysis. The rates of ICA overall (OR 1.57, 95%CI 1.36–1.81, p value < 0.001) and those without obstructive CAD (OR 6.63, 95%CI 4.79–9.16, p value < 0.001) were reduced in the CCTAFFR group, as compared to the control group. Moreover, CCT-FFR patients underwent coronary revascularization more frequently than patients in the control arm (OR 0.48,CI 0.38–0.62, p value < 0.001). There was no significance difference between the two strategies in terms of 1 year MACE (OR 1.11,CI 0.86–1.44, p value 0.42), nonfatal MI (OR 0.73, CI 0.41–1.33, p value 0.31), all-cause mortality (OR 1.29,CI 0.47–3.54, p value 0.63) and unplanned revascularization for angina (OR 0.99, 95%CI 0.65–1.49, p value 0.95).</div><div>Conclusions: In conclusion, in the management of stable CAD, the use of CCT-FFR was associated with lower overall rates of ICA but higher rates of coronary revascularization with comparable 1-year clinical impact.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"19 2","pages":"Pages 174-182"},"PeriodicalIF":5.8000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical impact of CCT-FFR as first-strategy in patients with symptomatic stable coronary artery disease: A systematic review and meta-analysis\",\"authors\":\"Gianluca Di Pietro , Riccardo Improta , Ovidio De Filippo , Francesco Bruno , Lucia Ilaria Birtolo , Emanuele Bruno , Nicola Galea , Marco Francone , Marc Dewey , Fabrizio D'Ascenzo , Massimo Mancone\",\"doi\":\"10.1016/j.jcct.2025.02.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Aims: Despite the promising results, the clinical implications of the CCT-FFR is already debated. This metanalysis aimed to determine the potential benefits of incorporating FFRCT into stable CAD management.</div><div>Methods: After searching for studies comparing outcomes of patients with suspected stable CAD who underwent CCT-FFR as a first strategy versus non-urgent cardiovascular testing after a clinical judgment, we calculated odds ratios (ORs) and 95 % confidence intervals (CIs) using a random-effects or fixed-effects meta-analysis model depending on heterogeneity significance.</div><div>Results: 5 studies (3 RCTs and 2 observational studies) globally encompassing 5282 patients (CCT-FFR = 2604 patients, Control Group = 2678 patients) were included in the quantitative analysis. The rates of ICA overall (OR 1.57, 95%CI 1.36–1.81, p value < 0.001) and those without obstructive CAD (OR 6.63, 95%CI 4.79–9.16, p value < 0.001) were reduced in the CCTAFFR group, as compared to the control group. Moreover, CCT-FFR patients underwent coronary revascularization more frequently than patients in the control arm (OR 0.48,CI 0.38–0.62, p value < 0.001). There was no significance difference between the two strategies in terms of 1 year MACE (OR 1.11,CI 0.86–1.44, p value 0.42), nonfatal MI (OR 0.73, CI 0.41–1.33, p value 0.31), all-cause mortality (OR 1.29,CI 0.47–3.54, p value 0.63) and unplanned revascularization for angina (OR 0.99, 95%CI 0.65–1.49, p value 0.95).</div><div>Conclusions: In conclusion, in the management of stable CAD, the use of CCT-FFR was associated with lower overall rates of ICA but higher rates of coronary revascularization with comparable 1-year clinical impact.</div></div>\",\"PeriodicalId\":49039,\"journal\":{\"name\":\"Journal of Cardiovascular Computed Tomography\",\"volume\":\"19 2\",\"pages\":\"Pages 174-182\"},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cardiovascular Computed Tomography\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1934592525000462\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Computed Tomography","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1934592525000462","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Clinical impact of CCT-FFR as first-strategy in patients with symptomatic stable coronary artery disease: A systematic review and meta-analysis
Aims: Despite the promising results, the clinical implications of the CCT-FFR is already debated. This metanalysis aimed to determine the potential benefits of incorporating FFRCT into stable CAD management.
Methods: After searching for studies comparing outcomes of patients with suspected stable CAD who underwent CCT-FFR as a first strategy versus non-urgent cardiovascular testing after a clinical judgment, we calculated odds ratios (ORs) and 95 % confidence intervals (CIs) using a random-effects or fixed-effects meta-analysis model depending on heterogeneity significance.
Results: 5 studies (3 RCTs and 2 observational studies) globally encompassing 5282 patients (CCT-FFR = 2604 patients, Control Group = 2678 patients) were included in the quantitative analysis. The rates of ICA overall (OR 1.57, 95%CI 1.36–1.81, p value < 0.001) and those without obstructive CAD (OR 6.63, 95%CI 4.79–9.16, p value < 0.001) were reduced in the CCTAFFR group, as compared to the control group. Moreover, CCT-FFR patients underwent coronary revascularization more frequently than patients in the control arm (OR 0.48,CI 0.38–0.62, p value < 0.001). There was no significance difference between the two strategies in terms of 1 year MACE (OR 1.11,CI 0.86–1.44, p value 0.42), nonfatal MI (OR 0.73, CI 0.41–1.33, p value 0.31), all-cause mortality (OR 1.29,CI 0.47–3.54, p value 0.63) and unplanned revascularization for angina (OR 0.99, 95%CI 0.65–1.49, p value 0.95).
Conclusions: In conclusion, in the management of stable CAD, the use of CCT-FFR was associated with lower overall rates of ICA but higher rates of coronary revascularization with comparable 1-year clinical impact.
期刊介绍：
The Journal of Cardiovascular Computed Tomography is a unique peer-review journal that integrates the entire international cardiovascular CT community including cardiologist and radiologists, from basic to clinical academic researchers, to private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our cardiovascular imaging community across the world. The goal of the journal is to advance the field of cardiovascular CT as the leading cardiovascular CT journal, attracting seminal work in the field with rapid and timely dissemination in electronic and print media.
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