{"title":"幽门螺杆菌相关的慢性萎缩性胃炎与胃癌风险的关系：文献综述。","authors":"Zefeng Zhang, Sitong Chen, Shudan Li, Yadan Zheng, Lifei Mai, Xiaoguang Zhang","doi":"10.3389/fmed.2025.1504749","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic atrophic gastritis (CAG) is considered to be closely related to <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and characterized by the atrophy and/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and <i>H. pylori</i> infection stimulates the development of atrophy and IM and the progression of gastric cancer through the persistent effect acting on the gastric mucosa, including releasing inflammatory factors such as Interleukin-8(IL-8). From the molecular biology perspective, growing evidence shows that <i>H. pylori</i> probably induce the expression of NF-κB, miR-204, miR-27a, hnRNPA2B1, and JARID1B, which play crucial roles in the progression of CAG into gastric cancer. In addition, <i>H. pylori</i> can increase Epstein-Barr virus (EBV) infection, and the co-infection will jointly increase gastric cancer risk. Furthermore, <i>H. pylori</i> induces cellular senescence and promotes atrophy progression and finally increases the gastric cancer risk. This review aims to explore the carcinogenic mechanisms of <i>H. pylori</i> related CAG in order to provide theoretical foundations for the pathogenesis mechanism and early detection and prevention of gastric cancer.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1504749"},"PeriodicalIF":3.6000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882515/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of <i>Helicobacter pylori</i> related chronic atrophic gastritis and gastric cancer risk: a literature review.\",\"authors\":\"Zefeng Zhang, Sitong Chen, Shudan Li, Yadan Zheng, Lifei Mai, Xiaoguang Zhang\",\"doi\":\"10.3389/fmed.2025.1504749\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Chronic atrophic gastritis (CAG) is considered to be closely related to <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and characterized by the atrophy and/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and <i>H. pylori</i> infection stimulates the development of atrophy and IM and the progression of gastric cancer through the persistent effect acting on the gastric mucosa, including releasing inflammatory factors such as Interleukin-8(IL-8). From the molecular biology perspective, growing evidence shows that <i>H. pylori</i> probably induce the expression of NF-κB, miR-204, miR-27a, hnRNPA2B1, and JARID1B, which play crucial roles in the progression of CAG into gastric cancer. In addition, <i>H. pylori</i> can increase Epstein-Barr virus (EBV) infection, and the co-infection will jointly increase gastric cancer risk. Furthermore, <i>H. pylori</i> induces cellular senescence and promotes atrophy progression and finally increases the gastric cancer risk. This review aims to explore the carcinogenic mechanisms of <i>H. pylori</i> related CAG in order to provide theoretical foundations for the pathogenesis mechanism and early detection and prevention of gastric cancer.</p>\",\"PeriodicalId\":12488,\"journal\":{\"name\":\"Frontiers in Medicine\",\"volume\":\"12 \",\"pages\":\"1504749\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882515/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fmed.2025.1504749\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1504749","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
慢性萎缩性胃炎（Chronic atro萎缩性胃炎，CAG）被认为与幽门螺杆菌（Helicobacter pylori， H. pylori）感染密切相关，病理上以胃黏膜萎缩和/或肠化生（IM）为特征。CAG常被认为是胃癌的癌前病变，幽门螺杆菌感染通过持续作用于胃黏膜，包括释放白细胞介素-8（IL-8）等炎症因子，刺激萎缩、IM的发生和胃癌的进展。从分子生物学角度来看，越来越多的证据表明，幽门螺杆菌可能诱导了NF-κB、miR-204、miR-27a、hnRNPA2B1和JARID1B的表达，这些基因在CAG发展为胃癌的过程中起着至关重要的作用。此外，幽门螺杆菌可增加eb病毒（Epstein-Barr virus， EBV）感染，两者共同感染会增加胃癌风险。此外，幽门螺杆菌诱导细胞衰老，促进萎缩进展，最终增加胃癌风险。本文旨在探讨幽门螺杆菌相关CAG的致癌机制，为胃癌的发病机制及早期发现和预防提供理论依据。
Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review.
Chronic atrophic gastritis (CAG) is considered to be closely related to Helicobacter pylori (H. pylori) infection and characterized by the atrophy and/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and H. pylori infection stimulates the development of atrophy and IM and the progression of gastric cancer through the persistent effect acting on the gastric mucosa, including releasing inflammatory factors such as Interleukin-8(IL-8). From the molecular biology perspective, growing evidence shows that H. pylori probably induce the expression of NF-κB, miR-204, miR-27a, hnRNPA2B1, and JARID1B, which play crucial roles in the progression of CAG into gastric cancer. In addition, H. pylori can increase Epstein-Barr virus (EBV) infection, and the co-infection will jointly increase gastric cancer risk. Furthermore, H. pylori induces cellular senescence and promotes atrophy progression and finally increases the gastric cancer risk. This review aims to explore the carcinogenic mechanisms of H. pylori related CAG in order to provide theoretical foundations for the pathogenesis mechanism and early detection and prevention of gastric cancer.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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