{"title":"作为肺部健康预测指标的 HRR：来自 NHANES 数据库的启示。","authors":"Jiaji Zhou, Wenyi Du, Hanzhou Huang, Yongqi Chen, Huixing Li, Leyan Chen, Feng Liu, Mingfeng Zheng","doi":"10.3389/fmed.2025.1503142","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic respiratory diseases (CRPD) are a global health threat characterized by oxidative stress, systemic inflammation, hypoxemia, and respiratory distress. Inflammatory indicators such as hemoglobin-to-red blood cell distribution width ratio (HRR) have been explored in relation to diseases of the respiratory system, but the correlation between HRR and pulmonary function has not been established. As part of this study, a representative sample of the National Health and Nutrition Examination Survey (NHANES) respondents aged 40 or over was used to examine the correlation between HRR and pulmonary function indices.</p><p><strong>Methods: </strong>Data from the 2007-2012 NHANES were used for this study. HRR and four pulmonary function parameters were compared using regression and subgroup analyses. The Restricted Cubic Spline (RCS) model was employed to find out if there are any non-linear relationships between these associations. Multiple sensitivity analyses were used to verify the correlation between the two.</p><p><strong>Results: </strong>After adjusting for confounding variables, the data showed that for each unit increase in HRR among the population as a whole, for each unit increase in HRR, FVC increased by 0.11, FEV1 increased by 0.22, peak expiratory flow (PEF) increased by 0.24 and forced expiratory flow at 25-75% (FEF25-75%) was elevated by 0.49. In addition, we determined linear and positive correlations between FVC, FEV1, PEF or PEF 25-75% and HRR by constructing the RCS model curves. The positive correlation between HRR and pulmonary function parameters was affirmed through sensitivity analysis. Furthermore, except for the PEF 25-75%, FVC, FEV1, PEF all showed a significant upward trend with the increase of HRR in non-Hispanic white female population.</p><p><strong>Conclusion: </strong>According to our study, HRR was positively correlated with FVC, FEV1, PEF, and PEF25-75% in a middle-aged and older adult US population. It would be useful to study the specific impact of HRR on pulmonary function and to investigate the potential pathophysiological mechanisms that might link them.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1503142"},"PeriodicalIF":3.1000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891021/pdf/","citationCount":"0","resultStr":"{\"title\":\"HRR as a predictor of lung health: insights from the NHANES database.\",\"authors\":\"Jiaji Zhou, Wenyi Du, Hanzhou Huang, Yongqi Chen, Huixing Li, Leyan Chen, Feng Liu, Mingfeng Zheng\",\"doi\":\"10.3389/fmed.2025.1503142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic respiratory diseases (CRPD) are a global health threat characterized by oxidative stress, systemic inflammation, hypoxemia, and respiratory distress. Inflammatory indicators such as hemoglobin-to-red blood cell distribution width ratio (HRR) have been explored in relation to diseases of the respiratory system, but the correlation between HRR and pulmonary function has not been established. As part of this study, a representative sample of the National Health and Nutrition Examination Survey (NHANES) respondents aged 40 or over was used to examine the correlation between HRR and pulmonary function indices.</p><p><strong>Methods: </strong>Data from the 2007-2012 NHANES were used for this study. HRR and four pulmonary function parameters were compared using regression and subgroup analyses. The Restricted Cubic Spline (RCS) model was employed to find out if there are any non-linear relationships between these associations. Multiple sensitivity analyses were used to verify the correlation between the two.</p><p><strong>Results: </strong>After adjusting for confounding variables, the data showed that for each unit increase in HRR among the population as a whole, for each unit increase in HRR, FVC increased by 0.11, FEV1 increased by 0.22, peak expiratory flow (PEF) increased by 0.24 and forced expiratory flow at 25-75% (FEF25-75%) was elevated by 0.49. In addition, we determined linear and positive correlations between FVC, FEV1, PEF or PEF 25-75% and HRR by constructing the RCS model curves. The positive correlation between HRR and pulmonary function parameters was affirmed through sensitivity analysis. Furthermore, except for the PEF 25-75%, FVC, FEV1, PEF all showed a significant upward trend with the increase of HRR in non-Hispanic white female population.</p><p><strong>Conclusion: </strong>According to our study, HRR was positively correlated with FVC, FEV1, PEF, and PEF25-75% in a middle-aged and older adult US population. It would be useful to study the specific impact of HRR on pulmonary function and to investigate the potential pathophysiological mechanisms that might link them.</p>\",\"PeriodicalId\":12488,\"journal\":{\"name\":\"Frontiers in Medicine\",\"volume\":\"12 \",\"pages\":\"1503142\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-02-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891021/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fmed.2025.1503142\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1503142","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
HRR as a predictor of lung health: insights from the NHANES database.
Background: Chronic respiratory diseases (CRPD) are a global health threat characterized by oxidative stress, systemic inflammation, hypoxemia, and respiratory distress. Inflammatory indicators such as hemoglobin-to-red blood cell distribution width ratio (HRR) have been explored in relation to diseases of the respiratory system, but the correlation between HRR and pulmonary function has not been established. As part of this study, a representative sample of the National Health and Nutrition Examination Survey (NHANES) respondents aged 40 or over was used to examine the correlation between HRR and pulmonary function indices.
Methods: Data from the 2007-2012 NHANES were used for this study. HRR and four pulmonary function parameters were compared using regression and subgroup analyses. The Restricted Cubic Spline (RCS) model was employed to find out if there are any non-linear relationships between these associations. Multiple sensitivity analyses were used to verify the correlation between the two.
Results: After adjusting for confounding variables, the data showed that for each unit increase in HRR among the population as a whole, for each unit increase in HRR, FVC increased by 0.11, FEV1 increased by 0.22, peak expiratory flow (PEF) increased by 0.24 and forced expiratory flow at 25-75% (FEF25-75%) was elevated by 0.49. In addition, we determined linear and positive correlations between FVC, FEV1, PEF or PEF 25-75% and HRR by constructing the RCS model curves. The positive correlation between HRR and pulmonary function parameters was affirmed through sensitivity analysis. Furthermore, except for the PEF 25-75%, FVC, FEV1, PEF all showed a significant upward trend with the increase of HRR in non-Hispanic white female population.
Conclusion: According to our study, HRR was positively correlated with FVC, FEV1, PEF, and PEF25-75% in a middle-aged and older adult US population. It would be useful to study the specific impact of HRR on pulmonary function and to investigate the potential pathophysiological mechanisms that might link them.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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