作为肺部健康预测指标的 HRR:来自 NHANES 数据库的启示。

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Frontiers in Medicine Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1503142
Jiaji Zhou, Wenyi Du, Hanzhou Huang, Yongqi Chen, Huixing Li, Leyan Chen, Feng Liu, Mingfeng Zheng
{"title":"作为肺部健康预测指标的 HRR:来自 NHANES 数据库的启示。","authors":"Jiaji Zhou, Wenyi Du, Hanzhou Huang, Yongqi Chen, Huixing Li, Leyan Chen, Feng Liu, Mingfeng Zheng","doi":"10.3389/fmed.2025.1503142","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic respiratory diseases (CRPD) are a global health threat characterized by oxidative stress, systemic inflammation, hypoxemia, and respiratory distress. Inflammatory indicators such as hemoglobin-to-red blood cell distribution width ratio (HRR) have been explored in relation to diseases of the respiratory system, but the correlation between HRR and pulmonary function has not been established. As part of this study, a representative sample of the National Health and Nutrition Examination Survey (NHANES) respondents aged 40 or over was used to examine the correlation between HRR and pulmonary function indices.</p><p><strong>Methods: </strong>Data from the 2007-2012 NHANES were used for this study. HRR and four pulmonary function parameters were compared using regression and subgroup analyses. The Restricted Cubic Spline (RCS) model was employed to find out if there are any non-linear relationships between these associations. Multiple sensitivity analyses were used to verify the correlation between the two.</p><p><strong>Results: </strong>After adjusting for confounding variables, the data showed that for each unit increase in HRR among the population as a whole, for each unit increase in HRR, FVC increased by 0.11, FEV1 increased by 0.22, peak expiratory flow (PEF) increased by 0.24 and forced expiratory flow at 25-75% (FEF25-75%) was elevated by 0.49. In addition, we determined linear and positive correlations between FVC, FEV1, PEF or PEF 25-75% and HRR by constructing the RCS model curves. The positive correlation between HRR and pulmonary function parameters was affirmed through sensitivity analysis. Furthermore, except for the PEF 25-75%, FVC, FEV1, PEF all showed a significant upward trend with the increase of HRR in non-Hispanic white female population.</p><p><strong>Conclusion: </strong>According to our study, HRR was positively correlated with FVC, FEV1, PEF, and PEF25-75% in a middle-aged and older adult US population. It would be useful to study the specific impact of HRR on pulmonary function and to investigate the potential pathophysiological mechanisms that might link them.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1503142"},"PeriodicalIF":3.1000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891021/pdf/","citationCount":"0","resultStr":"{\"title\":\"HRR as a predictor of lung health: insights from the NHANES database.\",\"authors\":\"Jiaji Zhou, Wenyi Du, Hanzhou Huang, Yongqi Chen, Huixing Li, Leyan Chen, Feng Liu, Mingfeng Zheng\",\"doi\":\"10.3389/fmed.2025.1503142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic respiratory diseases (CRPD) are a global health threat characterized by oxidative stress, systemic inflammation, hypoxemia, and respiratory distress. Inflammatory indicators such as hemoglobin-to-red blood cell distribution width ratio (HRR) have been explored in relation to diseases of the respiratory system, but the correlation between HRR and pulmonary function has not been established. As part of this study, a representative sample of the National Health and Nutrition Examination Survey (NHANES) respondents aged 40 or over was used to examine the correlation between HRR and pulmonary function indices.</p><p><strong>Methods: </strong>Data from the 2007-2012 NHANES were used for this study. HRR and four pulmonary function parameters were compared using regression and subgroup analyses. The Restricted Cubic Spline (RCS) model was employed to find out if there are any non-linear relationships between these associations. Multiple sensitivity analyses were used to verify the correlation between the two.</p><p><strong>Results: </strong>After adjusting for confounding variables, the data showed that for each unit increase in HRR among the population as a whole, for each unit increase in HRR, FVC increased by 0.11, FEV1 increased by 0.22, peak expiratory flow (PEF) increased by 0.24 and forced expiratory flow at 25-75% (FEF25-75%) was elevated by 0.49. In addition, we determined linear and positive correlations between FVC, FEV1, PEF or PEF 25-75% and HRR by constructing the RCS model curves. The positive correlation between HRR and pulmonary function parameters was affirmed through sensitivity analysis. Furthermore, except for the PEF 25-75%, FVC, FEV1, PEF all showed a significant upward trend with the increase of HRR in non-Hispanic white female population.</p><p><strong>Conclusion: </strong>According to our study, HRR was positively correlated with FVC, FEV1, PEF, and PEF25-75% in a middle-aged and older adult US population. It would be useful to study the specific impact of HRR on pulmonary function and to investigate the potential pathophysiological mechanisms that might link them.</p>\",\"PeriodicalId\":12488,\"journal\":{\"name\":\"Frontiers in Medicine\",\"volume\":\"12 \",\"pages\":\"1503142\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-02-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891021/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fmed.2025.1503142\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1503142","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

背景:慢性呼吸系统疾病(CRPD)是以氧化应激、全身炎症、低氧血症和呼吸困难为特征的全球性健康威胁。血红蛋白与红细胞分布宽度比(HRR)等炎症指标与呼吸系统疾病的关系已得到探讨,但 HRR 与肺功能之间的相关性尚未确定。作为本研究的一部分,我们使用了美国国家健康与营养调查(NHANES)中 40 岁及以上受访者的代表性样本,以研究 HRR 与肺功能指数之间的相关性:本研究使用了 2007-2012 年 NHANES 的数据。采用回归分析和亚组分析比较了 HRR 和四个肺功能参数。采用受限立方样条(RCS)模型来发现这些关联之间是否存在非线性关系。多重敏感性分析用于验证两者之间的相关性:在对混杂变量进行调整后,数据显示,整个人群的 HRR 每增加一个单位,FVC 增加 0.11,FEV1 增加 0.22,呼气峰流速(PEF)增加 0.24,25-75% 时的用力呼气流速(FEF25-75%)增加 0.49。此外,我们还通过构建 RCS 模型曲线,确定了 FVC、FEV1、PEF 或 PEF 25-75% 与 HRR 之间的线性正相关关系。通过敏感性分析,我们确认了 HRR 与肺功能参数之间的正相关性。此外,在非西班牙裔白人女性人群中,除 PEF 25-75% 外,FVC、FEV1、PEF 均随着 HRR 的增加呈显著上升趋势:根据我们的研究,在美国中老年人群中,HRR 与 FVC、FEV1、PEF 和 PEF25-75% 呈正相关。研究 HRR 对肺功能的具体影响,并探讨可能将它们联系在一起的潜在病理生理机制,将大有裨益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
HRR as a predictor of lung health: insights from the NHANES database.

Background: Chronic respiratory diseases (CRPD) are a global health threat characterized by oxidative stress, systemic inflammation, hypoxemia, and respiratory distress. Inflammatory indicators such as hemoglobin-to-red blood cell distribution width ratio (HRR) have been explored in relation to diseases of the respiratory system, but the correlation between HRR and pulmonary function has not been established. As part of this study, a representative sample of the National Health and Nutrition Examination Survey (NHANES) respondents aged 40 or over was used to examine the correlation between HRR and pulmonary function indices.

Methods: Data from the 2007-2012 NHANES were used for this study. HRR and four pulmonary function parameters were compared using regression and subgroup analyses. The Restricted Cubic Spline (RCS) model was employed to find out if there are any non-linear relationships between these associations. Multiple sensitivity analyses were used to verify the correlation between the two.

Results: After adjusting for confounding variables, the data showed that for each unit increase in HRR among the population as a whole, for each unit increase in HRR, FVC increased by 0.11, FEV1 increased by 0.22, peak expiratory flow (PEF) increased by 0.24 and forced expiratory flow at 25-75% (FEF25-75%) was elevated by 0.49. In addition, we determined linear and positive correlations between FVC, FEV1, PEF or PEF 25-75% and HRR by constructing the RCS model curves. The positive correlation between HRR and pulmonary function parameters was affirmed through sensitivity analysis. Furthermore, except for the PEF 25-75%, FVC, FEV1, PEF all showed a significant upward trend with the increase of HRR in non-Hispanic white female population.

Conclusion: According to our study, HRR was positively correlated with FVC, FEV1, PEF, and PEF25-75% in a middle-aged and older adult US population. It would be useful to study the specific impact of HRR on pulmonary function and to investigate the potential pathophysiological mechanisms that might link them.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
期刊最新文献
Corrigendum: Same duodenal neuroendocrine tumors, different endoscopic resection methods: a case report and literature review. Editorial: Precision medicine: biomarker testing for diagnosis and treatment of cardiovascular disease. Editorial: Update on glaucoma research: from basic science to clinical practice. Exploration of key genes associated with oxidative stress in polycystic ovary syndrome and experimental validation. Pedagogical strategies for supporting learning and student well-being in environmentally sustainable healthcare.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1