IF 5.3 2区 医学 Q1 IMMUNOLOGY Transplantation Pub Date : 2025-03-11 DOI:10.1097/TP.0000000000005360
Teija Madhusoodanan, David P Schladt, Grace R Lyden, Cinthia Lozano, Jonathan M Miller, Joshua Pyke, Tim Weaver, Ajay K Israni, Warren T McKinney
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摘要

背景:与慢性透析相比,肾移植可提供更好的治疗效果并降低成本。然而,尽管我们努力扩大肾移植的机会并改善已故捐献者分配的公平性,但肾移植机会的种族和民族差异依然存在。我们的目的是在 2014 年分配系统发生变化后,评估种族和民族与获得已故捐献者肾移植(DDKT)机会之间的关系:这项回顾性研究评估了自 2014 年肾脏分配系统实施以来列入名单后获得 DDKT 的情况。候选名单状态和移植结果由移植受者科学登记处的数据确定。我们的分析包括从 2015 年 1 月 1 日到 2023 年 6 月 30 日在美国等待名单上的所有成人肾移植候选人:结果:在研究期间,共有 290 763 名候选者在 DDKT 候选名单上。其中,非裔美国人占 36.4%,拉丁裔占 22.2%。与非拉丁裔白人患者相比,非裔美国人(未经调整的危险比[HR],0.93;95% 置信区间[CI],0.92-0.94)和拉丁裔患者(未经调整的危险比,0.88;95% 置信区间[CI],0.87-0.90)挂号后获得 DDKT 的机会减少。在控制了人口统计学和临床因素后,非裔美国人(HR,0.78;95% CI,0.77-0.80)和拉丁裔患者(HR,0.73;95% CI,0.72-0.74)在接受移植方面的差异大幅扩大:结论:非裔美国人和拉丁裔患者在列名后获得 DDKT 的机会减少。结论:非裔美国人和拉丁裔患者在挂号后获得 DDKT 的机会减少,需要更有效的方法来改善非裔美国人和拉丁裔患者在挂号后获得 DDKT 的机会。
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Access to Transplant for African American and Latino Patients Under the 2014 US Kidney Allocation System.

Background: Kidney transplant offers better outcomes and reduced costs compared with chronic dialysis. However, racial and ethnic disparities in access to kidney transplant persist despite efforts to expand access to transplant and improve the equity of deceased donor allocation. Our objective was to evaluate after listing the association of race and ethnicity with access to deceased donor kidney transplant (DDKT) after changes to the allocation system in 2014.

Methods: This retrospective study evaluated access to DDKT after listing since the implementation of the 2014 kidney allocation system. Waitlist status and transplant outcomes were ascertained from data from the Scientific Registry of Transplant Recipients. Our analysis included every adult kidney transplant candidate on the waiting list in the US from January 1, 2015, through June 30, 2023.

Results: A total of 290 763 candidates were on the waiting list for DDKT during the study period. Of these, 36.4% of candidates were African American and 22.2% were Latino. Compared with White non-Latino patients, access to DDKT after listing was reduced for African American (unadjusted hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.92-0.94) and Latino individuals (unadjusted HR, 0.88; 95% CI, 0.87-0.90). After controlling for demographic and clinical factors, these differences in access to transplant widened substantially for African American (HR, 0.78; 95% CI, 0.77-0.80) and Latino patients (HR, 0.73; 95% CI, 0.72-0.74).

Conclusions: African American and Latino patients had reduced access to DDKT after listing. More effective approaches to improving access for African American and Latino individuals after listing are needed.

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来源期刊
Transplantation
Transplantation 医学-免疫学
CiteScore
8.50
自引率
11.30%
发文量
1906
审稿时长
1 months
期刊介绍: The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation. ​
期刊最新文献
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