Kyu Hong Kim, Jong Bo Park, Jung Nam An, Gaeun Bae, Kyu Hyeon Kim, Seong Joon Park, Youngjin Jung, Yong Chul Kim, Jung Pyo Lee, Jae Wook Lee, Dong Ki Kim, Yon Su Kim, Byung Hee Hong, Seung Hee Yang
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引用次数: 0
摘要
治疗肾病的新型纳米药物结节细胞损伤是蛋白尿性肾小球疾病的标志。在编号为 2410747 的文章中，Seung Hee Yang、Byung Hee Hong、Yon Su Kim 及其同事揭示了石墨烯量子点 (GQDs) 作为对抗肾毒性和慢性肾病 (CKD) 的前沿治疗策略。通过选择性抑制瞬时受体电位通道 5（TRPC5）的活性，GQDs 能有效抑制炎症、纤维化和细胞凋亡，从而保持细胞内钙的平衡。此外，GQDs 还能增强肾脏荚膜细胞的线粒体膜电位，从而保护肾功能并改善与荚膜细胞相关的损伤。
Effects of Graphene Quantum Dots on Renal Fibrosis Through Alleviating Oxidative Stress and Restoring Mitochondrial Membrane Potential (Adv. Sci. 10/2025)
Novel Nanomedicine for Kidney Disease
Podocyte injury is a hallmark of proteinuric glomerular diseases. In article number 2410747, Seung Hee Yang, Byung Hee Hong, Yon Su Kim, and colleagues unveil graphene quantum dots (GQDs) as a cutting-edge therapeutic strategy for combating nephrotoxicity and chronic kidney disease (CKD). By selectively inhibiting transient receptor potential channel 5 (TRPC5) activity, GQDs effectively suppress inflammation, fibrosis, and apoptosis, thereby preserving intracellular calcium homeostasis. Furthermore, GQDs enhance mitochondrial membrane potential in kidney podocytes, safeguarding renal function and ameliorating podocyte-related injuries.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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