Xianhe Fang , Jiaxing Lv , Shuxin Yang , Mingyu Ma , Runzhe Yang , Yi Bi
{"title":"十钨酸盐光催化合成3,3-二取代氧吲哚的级联C(sp3)-氢键功能化/环化反应","authors":"Xianhe Fang , Jiaxing Lv , Shuxin Yang , Mingyu Ma , Runzhe Yang , Yi Bi","doi":"10.1016/j.tet.2025.134578","DOIUrl":null,"url":null,"abstract":"<div><div>Herein, we describe a cascade C(sp<sup>3</sup>)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles. The reaction is catalyzed by decatungstate anion under near-ultraviolet light irradiation. Functionalization of aliphatic C(sp<sup>3</sup>)−H bonds occurs efficiently through this catalytic reaction. Furthermore, the selected products exhibited inhibitory effects on LPS-induced macrophage nitric oxide release.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"177 ","pages":"Article 134578"},"PeriodicalIF":2.2000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cascade C(sp3)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles by decatungstate photocatalysis\",\"authors\":\"Xianhe Fang , Jiaxing Lv , Shuxin Yang , Mingyu Ma , Runzhe Yang , Yi Bi\",\"doi\":\"10.1016/j.tet.2025.134578\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Herein, we describe a cascade C(sp<sup>3</sup>)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles. The reaction is catalyzed by decatungstate anion under near-ultraviolet light irradiation. Functionalization of aliphatic C(sp<sup>3</sup>)−H bonds occurs efficiently through this catalytic reaction. Furthermore, the selected products exhibited inhibitory effects on LPS-induced macrophage nitric oxide release.</div></div>\",\"PeriodicalId\":437,\"journal\":{\"name\":\"Tetrahedron\",\"volume\":\"177 \",\"pages\":\"Article 134578\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040402025001346\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402025001346","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/11 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Cascade C(sp3)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles by decatungstate photocatalysis
Herein, we describe a cascade C(sp3)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles. The reaction is catalyzed by decatungstate anion under near-ultraviolet light irradiation. Functionalization of aliphatic C(sp3)−H bonds occurs efficiently through this catalytic reaction. Furthermore, the selected products exhibited inhibitory effects on LPS-induced macrophage nitric oxide release.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
