黑色素瘤的临床TIL经验：过去，现在，未来

IF 4.4 3区医学 Q2 HEMATOLOGY Transplantation and Cellular Therapy Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI:10.1016/j.jtct.2024.11.013

James W. Smithy , Adam J. Schoenfeld , Allison Betof Warner

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引用次数: 0

摘要

美国食品和药物管理局（fda）最近于2024年2月批准了lifileucel，这是30多年来肿瘤浸润淋巴细胞（til）过继细胞疗法治疗不可切除黑色素瘤研究的高潮。在这篇综述中，我们强调了TIL治疗黑色素瘤的关键历史数据，以及正在进行的提高其疗效和适用性的努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Clinical TIL Experience in Melanoma: Past, Present, Future

The recent approval of lifileucel by the US Food and Drug Administration in February 2024 was the culmination of over 3 decades of research in adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) for unresectable melanoma. In this review, we highlight key historical data for TIL therapy in melanoma as well as ongoing efforts to improve its efficacy and applicability.

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