IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2025-03-05 DOI:10.3390/diagnostics15050628
Tomoaki Hara, Sikun Meng, Aya Hasan Alshammari, Hideyuki Hatakeyama, Yasuko Arao, Yoshiko Saito, Kana Inoue, Eric di Luccio, Andrea Vecchione, Takaaki Hirotsu, Hideshi Ishii
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引用次数: 0

摘要

与正常细胞相比,癌细胞表现出异常行为。它们无视生长抑制信号,如接触抑制(一种在与周围细胞碰撞时阻止其增殖的机制),以不受控制的方式增殖,破坏组织。因此,癌症的早期发现和治疗对健康长寿非常重要。癌细胞与正常细胞不同,它们的基因表达因其异常而具有特征。人们一直在寻找能反映这些特征的癌症标记物,并将其应用于诊断。虽然血液抗原分析一直是主要方法,但仍需进一步开发诊断系统,以便早期发现癌症。下一代测序仪改进了基因表达分析技术,使详细分析癌细胞中的基因表达和血液或尿液中的核酸分子成为可能。此外,癌细胞会释放细胞外囊泡--外泌体,已知其中含有可作为癌症标志物的分子。本综述总结了有关外泌体癌症标志物的最新研究成果。
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Recent Exploration of Solid Cancer Biomarkers Hidden Within Urine or Blood Exosomes That Provide Fundamental Information for Future Cancer Diagnostics.

Cancer cells exhibit abnormal behavior compared to normal cells. They ignore growth arrest signals such as contact inhibition, a mechanism that stops their proliferation when they collide with surrounding cells, and proliferate in an uncontrolled manner, destroying tissue. Early detection and treatment of cancer are therefore important for healthy longevity. Cancer cells differ from normal cells in their characteristic gene expression due to their abnormalities. Cancer markers that reflect these characteristics have been searched for and applied to diagnosis. Although analysis of blood antigens has been the main method, further development of a diagnostic system is needed for early detection of cancer. Next-generation sequencers have improved gene expression analysis technology, making it possible to analyze detailed gene expression in cancer cells and nucleic acid molecules in blood or urine. In addition, cancer cells release extracellular vesicles, exosomes, which are known to contain molecules that may serve as cancer markers. This review summarizes the latest findings on exosomal cancer markers.

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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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