{"title":"68Ga-FAPI PET评估卵巢癌的meta分析。","authors":"Lixin Sun, Lichun Zheng, Bingye Zhang","doi":"10.1016/j.acra.2025.02.040","DOIUrl":null,"url":null,"abstract":"<div><h3>Rationale and Objectives</h3><div>The objective of this research is to carry out a systematic review and meta-analysis to detect the diagnostic efficacy of 68Ga-FAPI Positron Emission Tomography (PET) Computed Tomography/Magnetic Resonance (CT/MR) in total of the lesions as well as different aspects of metastasis in individuals with ovarian cancers (OC).</div></div><div><h3>Materials and Methods</h3><div>The PubMed, Embase, Cochrane library, and Web of Science databases were thoroughly searched until the cut-off date of July 23, 2024. The assessment of 68Ga-FAPI PET CT/MR of OC was presented by the included studies. Bivariate random effects models were utilized to compute the sensitivity and specificity of 68Ga-FAPI PET CT/MR in OC. The I-square index (I<sup>2</sup>) was utilized to measure heterogeneity and sensitivity analysis were employed to test it.</div></div><div><h3>Results</h3><div>The pooled sensitivity as well as specificity for 68Ga-FAPI PET CT/MR in OC were 0.90 (95% CI: 0.84-0.95) as well as 0.95 (95% CI: 0.91-0.97), correspondingly. In the subanalysis for metastatic lesions (lymph node [LN] metastases and peritoneal involvement), the pooled sensitivity and specificity of 68Ga-FAPI PET CT/MR were 0.94 (95% CI: 0.74-0.99) and 0.95 (95% CI: 0.84-0.99) for identifying metastatic LNs as well as 0.93 (95% CI: 0.81-0.97) and 0.96 (95% CI: 0.89-0.99) about peritoneal carcinomatosis evaluation, correspondingly. In the head-to-head comparison with 18F-FDG PET/CT, 68Ga-FAPI PET CT/MR exhibited a better sensitivity in identifying peritoneal metastases (<em>P</em> <!-->=<!--> <!-->.0004).</div></div><div><h3>Conclusion</h3><div>68Ga-FAPI PET CT/MR displayed a high overall diagnostic effectiveness in OC. When evaluating metastatic peritoneal lesions of OC, 68Ga-FAPI PET CT/MR displayed a superior pooled sensitivity.</div></div>","PeriodicalId":50928,"journal":{"name":"Academic Radiology","volume":"32 7","pages":"Pages 4082-4090"},"PeriodicalIF":3.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Meta-analysis of 68Ga-FAPI PET in Assessment of Ovarian Cancer\",\"authors\":\"Lixin Sun, Lichun Zheng, Bingye Zhang\",\"doi\":\"10.1016/j.acra.2025.02.040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Rationale and Objectives</h3><div>The objective of this research is to carry out a systematic review and meta-analysis to detect the diagnostic efficacy of 68Ga-FAPI Positron Emission Tomography (PET) Computed Tomography/Magnetic Resonance (CT/MR) in total of the lesions as well as different aspects of metastasis in individuals with ovarian cancers (OC).</div></div><div><h3>Materials and Methods</h3><div>The PubMed, Embase, Cochrane library, and Web of Science databases were thoroughly searched until the cut-off date of July 23, 2024. The assessment of 68Ga-FAPI PET CT/MR of OC was presented by the included studies. Bivariate random effects models were utilized to compute the sensitivity and specificity of 68Ga-FAPI PET CT/MR in OC. The I-square index (I<sup>2</sup>) was utilized to measure heterogeneity and sensitivity analysis were employed to test it.</div></div><div><h3>Results</h3><div>The pooled sensitivity as well as specificity for 68Ga-FAPI PET CT/MR in OC were 0.90 (95% CI: 0.84-0.95) as well as 0.95 (95% CI: 0.91-0.97), correspondingly. In the subanalysis for metastatic lesions (lymph node [LN] metastases and peritoneal involvement), the pooled sensitivity and specificity of 68Ga-FAPI PET CT/MR were 0.94 (95% CI: 0.74-0.99) and 0.95 (95% CI: 0.84-0.99) for identifying metastatic LNs as well as 0.93 (95% CI: 0.81-0.97) and 0.96 (95% CI: 0.89-0.99) about peritoneal carcinomatosis evaluation, correspondingly. In the head-to-head comparison with 18F-FDG PET/CT, 68Ga-FAPI PET CT/MR exhibited a better sensitivity in identifying peritoneal metastases (<em>P</em> <!-->=<!--> <!-->.0004).</div></div><div><h3>Conclusion</h3><div>68Ga-FAPI PET CT/MR displayed a high overall diagnostic effectiveness in OC. When evaluating metastatic peritoneal lesions of OC, 68Ga-FAPI PET CT/MR displayed a superior pooled sensitivity.</div></div>\",\"PeriodicalId\":50928,\"journal\":{\"name\":\"Academic Radiology\",\"volume\":\"32 7\",\"pages\":\"Pages 4082-4090\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Academic Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1076633225001837\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Academic Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1076633225001837","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
理由与目的：本研究的目的是通过系统回顾和荟萃分析，检测68Ga-FAPI正电子发射断层扫描（PET）、计算机断层扫描(CT) /磁共振（mri）对卵巢癌（OC）患者病变及转移不同方面的诊断效果。材料和方法：PubMed、Embase、Cochrane图书馆和Web of Science数据库被彻底检索，截止日期为2024年7月23日。纳入的研究给出了68Ga-FAPI PET CT/MR对OC的评估。采用双变量随机效应模型计算68Ga-FAPI PET CT/MR在OC中的敏感性和特异性。采用i平方指数（I2）衡量异质性，采用敏感性分析进行检验。结果：68Ga-FAPI PET CT/MR诊断OC的敏感性和特异性分别为0.90 （95% CI: 0.84 ~ 0.95）和0.95 （95% CI: 0.91 ~ 0.97）。在转移病灶（淋巴结[LN]转移和腹膜累及）的亚分析中，68Ga-FAPI PET CT/MR鉴别转移性淋巴结的总敏感性和特异性分别为0.94 （95% CI: 0.74-0.99）和0.95 (95% CI: 0.84-0.99)，鉴别腹膜癌的总敏感性和特异性分别为0.93 （95% CI: 0.81-0.97）和0.96 （95% CI: 0.89-0.99）。在与18F-FDG PET/CT的头对头比较中，68Ga-FAPI PET CT/MR在识别腹膜转移方面表现出更好的敏感性（P= 0.0004）。结论：68Ga-FAPI PET CT/MR对OC具有较高的综合诊断效能。在评估OC的转移性腹膜病变时，68Ga-FAPI PET CT/MR显示出优越的综合敏感性。
A Meta-analysis of 68Ga-FAPI PET in Assessment of Ovarian Cancer
Rationale and Objectives
The objective of this research is to carry out a systematic review and meta-analysis to detect the diagnostic efficacy of 68Ga-FAPI Positron Emission Tomography (PET) Computed Tomography/Magnetic Resonance (CT/MR) in total of the lesions as well as different aspects of metastasis in individuals with ovarian cancers (OC).
Materials and Methods
The PubMed, Embase, Cochrane library, and Web of Science databases were thoroughly searched until the cut-off date of July 23, 2024. The assessment of 68Ga-FAPI PET CT/MR of OC was presented by the included studies. Bivariate random effects models were utilized to compute the sensitivity and specificity of 68Ga-FAPI PET CT/MR in OC. The I-square index (I2) was utilized to measure heterogeneity and sensitivity analysis were employed to test it.
Results
The pooled sensitivity as well as specificity for 68Ga-FAPI PET CT/MR in OC were 0.90 (95% CI: 0.84-0.95) as well as 0.95 (95% CI: 0.91-0.97), correspondingly. In the subanalysis for metastatic lesions (lymph node [LN] metastases and peritoneal involvement), the pooled sensitivity and specificity of 68Ga-FAPI PET CT/MR were 0.94 (95% CI: 0.74-0.99) and 0.95 (95% CI: 0.84-0.99) for identifying metastatic LNs as well as 0.93 (95% CI: 0.81-0.97) and 0.96 (95% CI: 0.89-0.99) about peritoneal carcinomatosis evaluation, correspondingly. In the head-to-head comparison with 18F-FDG PET/CT, 68Ga-FAPI PET CT/MR exhibited a better sensitivity in identifying peritoneal metastases (P = .0004).
Conclusion
68Ga-FAPI PET CT/MR displayed a high overall diagnostic effectiveness in OC. When evaluating metastatic peritoneal lesions of OC, 68Ga-FAPI PET CT/MR displayed a superior pooled sensitivity.
期刊介绍：
Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.
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