{"title":"ni催化C(sp3) -C （sp3）交叉偶联制备γ-羰基烷基硼酸盐和烷基硅","authors":"Linfei Zhu , Yang Sun , Hui Wang","doi":"10.1039/d5qo00320b","DOIUrl":null,"url":null,"abstract":"<div><div>A nickel-catalyzed C(sp<sup>3</sup>)–C(sp<sup>3</sup>) ring-opening cross-coupling reaction of cyclopropanols with α-boryl and α-silyl electrophiles is presented, offering an efficient route to access γ-carbonyl alkylboronates and alkylsilicons under mild conditions. The practical applicability of this method is illustrated by the gram-scale synthesis and various transformations of alkylboronates.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 12","pages":"Pages 3587-3593"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ni-catalyzed C(sp3)–C(sp3) cross-coupling to access γ-carbonyl alkylboronates and alkylsilicons enabled by cyclopropanol-derived homoenolates†\",\"authors\":\"Linfei Zhu , Yang Sun , Hui Wang\",\"doi\":\"10.1039/d5qo00320b\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A nickel-catalyzed C(sp<sup>3</sup>)–C(sp<sup>3</sup>) ring-opening cross-coupling reaction of cyclopropanols with α-boryl and α-silyl electrophiles is presented, offering an efficient route to access γ-carbonyl alkylboronates and alkylsilicons under mild conditions. The practical applicability of this method is illustrated by the gram-scale synthesis and various transformations of alkylboronates.</div></div>\",\"PeriodicalId\":94379,\"journal\":{\"name\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"volume\":\"12 12\",\"pages\":\"Pages 3587-3593\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2052412925002049\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412925002049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/18 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Ni-catalyzed C(sp3)–C(sp3) cross-coupling to access γ-carbonyl alkylboronates and alkylsilicons enabled by cyclopropanol-derived homoenolates†
A nickel-catalyzed C(sp3)–C(sp3) ring-opening cross-coupling reaction of cyclopropanols with α-boryl and α-silyl electrophiles is presented, offering an efficient route to access γ-carbonyl alkylboronates and alkylsilicons under mild conditions. The practical applicability of this method is illustrated by the gram-scale synthesis and various transformations of alkylboronates.
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