Andrew E.H. Elia, Snehanshu Chowdhury, William R. DeNight
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Lost in translation: SLFN11 induces p53-independent apoptosis
A recent study in Molecular Cell by Ogawa et al.1 demonstrates that the protein SLFN11, which is a potent biomarker for sensitivity to DNA damage, induces p53-independent apoptosis through inhibition of protein translation.
期刊介绍：
Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
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