Zhe-Wen Chen, Yuan Wang, Rong Chao, Tai-Zong Wu, Tian-Hua Zhong, Xian-Wen Yang, Bin Wang
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引用次数: 0
摘要
从深海来源的paxilli青霉MCCC 3A01133中分离到一种罕见的三非非雀稗吲哚二萜（penpaxin A, 1）、一种新的1,3-二恶烷衍生物（penpaxin B, 9）和19个已知化合物（2-8和10-21）。新化合物的结构是通过NMR， HRESIMS和ORD数据的详细分析确定的。3-Deoxo-4b-deoxypaxilline(5)和paspaline(7)对RSL3诱导的铁下垂有较强的抑制作用，EC50值分别为2.88和0.21 μM。
Chemical Constituents with Ferroptosis Inhibitory Activity of the Deep-Sea-Derived Penicillium paxilli
A rare tri-nor-non-paspaline indole diterpenoid (penpaxin A, 1), a new 1,3-dioxolane derivative (penpaxin B, 9), and 19 known compounds (2–8 and 10–21) were isolated from the deep-sea-derived Penicillium paxilli MCCC 3A01133. The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and ORD data. 3-Deoxo-4b-deoxypaxilline (5) and paspaline (7) exhibited potent inhibition on RSL3-induced ferroptosis with the EC50 values of 2.88 and 0.21 µM, respectively.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
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