Mei-Chen Li , Jing-Jing Liu , Jie Liu , Hong-Yun Bai , Ming-Ming Zhao , Jian-Yu Liu , Yong-Nan Xu , Xu-Hong Ren
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引用次数: 0
摘要
硫脲素广泛分布于菊科、菊科和豆科等不同的自然科中。自分离以来，现代药理学研究发现该化合物具有神经保护、抗氧化、抗癌、保肝、抗菌、抗炎、抗糖尿病等多种生物活性，其作用机制与NF-κB、PI3K/AKT/mTOR、Nrf2/HO1、MAPKs、JNK/ERK等重要分子靶点有关。然而，自从这种化合物被发现以来，在互联网上没有搜索到全面和批判性的评论，这已经被承认了七十多年。因此，本文通过检索Scifinder、Web of Science、CNKI、PubMed和Plant List （www.theplantlist.org）等已发表的数据库和书籍，对1953年至2024年间硫维甙的药理作用进行了综合总结。通过这一综述，我们希望对硫维素的进一步研究将重点放在机制探索和毒性评价上，然后进行相关的临床评价。
Sulfuretin: Unraveling its potent therapeutic potential in a holistic literature review
Sulfuretin is widely distributed in different families of nature, such as Anacardiaceae, Compositae and Leguminosae. Since it was isolated, modern pharmacological researches revealed that this compound exhibited various bioactivities, namely neuroprotection, antioxidant, anti-cancer, hepatoprotection, anti-microbial, anti-inflammation, anti-diabetes, etc., which were attributed to many important molecular targets, such as NF-κB, PI3K/AKT/mTOR, Nrf2/HO1, MAPKs and JNK/ERK. However, there was no comprehensive and critical review of this compound searched on the Internet since it was discovered, which have been recognized for more than seventy years. Hence, this review comprehensively summarizes the pharmacological effects of sulfuretin (from 1953 to 2024) by searching Scifinder, Web of Science, CNKI, PubMed and the Plant List (www.theplantlist.org) as well as other published databases and books. By this review, we hope that further study of sulfuretin will focus on the mechanism exploration and to evaluate its toxicity, then to perform related clinical assessment.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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