山茶叶中5种未描述的酰化齐墩烷皂苷A-E及其α-葡萄糖苷酶抑制活性

IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2025-03-21 DOI:10.1002/cbdv.202500694
Pham Hai Yen, Nguyen Thi Cuc, Duong Thi Dung, Do Thi Trang, Ngo Anh Bang, Nguyen Viet Dung, Dan Thi Thuy Hang, Nguyen Huy Hoang, Phan Thi Thanh Huong, Bui Huu Tai, Phan Van Kiem
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引用次数: 0

摘要

从茶树叶中分离得到5个未描述的酰化齐墩烷皂苷(1-5)和5个已知化合物(6-10)。通过IR、HR-ESI-MS、1D和2D NMR对其化学结构进行了表征。化合物1 ~ 10显著抑制α-葡萄糖苷酶,IC50值在2.11±0.18 ~ 10.42±0.41µM范围内。
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Camehakosides A–E, Five Undescribed Acylated Oleanane Saponins From the Leaves of Camellia hakodae With Their α-Glucosidase Inhibitory Activity

Five undescribed acylated oleanane saponins (1–5), together with five known compounds (6–10) were isolated from the leaves of Camellia hakodae. Their chemical structures were determined by infrared, high-resolution electrospray ionization mass spectrometry, and one-dimensional and two-dimensional nuclear magnetic resonance spectra. Compounds 1–10 significantly inhibited α-glucosidase with IC50 values ranging from 2.11 ± 0.18 to 10.42 ± 0.41 µM.

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来源期刊
Chemistry & Biodiversity
Chemistry & Biodiversity 环境科学-化学综合
CiteScore
3.40
自引率
10.30%
发文量
475
审稿时长
2.6 months
期刊介绍: Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.
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