{"title":"通过酸性脱芳- zn /AcOH还原消除序列正式合成（±）-Lycoramine","authors":"Shan-Shan Chen, Xiao-Yang Bi, Bao-Yu Li, Jia-Jun Sui, Zhao-Nan Cai, Hong-Bo Qin","doi":"10.1016/j.tetlet.2025.155535","DOIUrl":null,"url":null,"abstract":"<div><div>Formal synthesis of (±)-lycoramine was described. The key reaction features a dearomatization-Zn/AcOH promoted reductive elimination sequence, followed by a chemoselective reduction of the double bond in enone yielding compound 1, a key intermediate in the total synthesis of (±)- lycoramine.</div><div>2024 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"160 ","pages":"Article 155535"},"PeriodicalIF":1.5000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Formal synthesis of (±)-Lycoramine via an acidic Dearomatization–Zn/AcOH reductive elimination sequence\",\"authors\":\"Shan-Shan Chen, Xiao-Yang Bi, Bao-Yu Li, Jia-Jun Sui, Zhao-Nan Cai, Hong-Bo Qin\",\"doi\":\"10.1016/j.tetlet.2025.155535\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Formal synthesis of (±)-lycoramine was described. The key reaction features a dearomatization-Zn/AcOH promoted reductive elimination sequence, followed by a chemoselective reduction of the double bond in enone yielding compound 1, a key intermediate in the total synthesis of (±)- lycoramine.</div><div>2024 Elsevier Ltd. All rights reserved.</div></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":\"160 \",\"pages\":\"Article 155535\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S004040392500084X\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S004040392500084X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Formal synthesis of (±)-Lycoramine via an acidic Dearomatization–Zn/AcOH reductive elimination sequence
Formal synthesis of (±)-lycoramine was described. The key reaction features a dearomatization-Zn/AcOH promoted reductive elimination sequence, followed by a chemoselective reduction of the double bond in enone yielding compound 1, a key intermediate in the total synthesis of (±)- lycoramine.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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