Bo-Wen Wang, Yan-Lin Pu, Run-Ze Li, Bai-Yang Li, Hai-Juan Jiao, Yin-Liang Bai, Wen Bao, Ye Zhang, Dao-Yong Zhu, Shao-Hua Wang
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An Acetic Acid-Promoted Strecker Type Reaction of N,N-Disubstituted Aminomalononitriles: An Efficient Way for the Construction of α-Aminonitriles
A Strecker type reaction between aldehydes and readily available N,N-disubstituted aminomalononitriles has been realized for the first time to give an alternative strategy for the synthesis of α-aminonitriles. This reaction features broad substrate scope and the use of water as solvent, and its utility has been supported by the formal synthesis of racemic Clopidogrel and a 3-aminoindole type of compound.
期刊介绍：
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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