{"title":"脑啡肽类似物tyr - d - ala - gly - ph - cys (Et)和tyr - d - ala - gly - ph - cys (Bu)对大鼠泌乳素和生长激素释放的影响。","authors":"J Nedvídková, E Kasafírek, A Dlabac","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of natural Met-enkephalin and its analogues Tyr-D-Ala-Gly-Phe-Cys(Et) (I) and Tyr-D-Ala-Gly-Phe-Cys(Bu) (II) on serum rat prolactin and rat growth hormone levels in male rats has been studied. Met-enkephalin and both analogues increased serum growth hormone and prolactin concentration, analogue I being the most potent. Enkephalin analogue I, with isosteric isomer of methionine in Met-enkephalin, and analogue II with butyl residue showed a lower stimulatory effect than natural Met-enkephalin. Stimulatory effect of analogues I and II on prolactin and growth hormone release was found to be reversed by a simultaneous treatment with the opiate antagonist naloxone.</p>","PeriodicalId":11547,"journal":{"name":"Endocrinologia experimentalis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of enkephalin analogues Tyr-D-Ala-Gly-Phe-Cys(Et) and Tyr-D-Ala-Gly-Phe-Cys(Bu) on prolactin and growth hormone release in rats.\",\"authors\":\"J Nedvídková, E Kasafírek, A Dlabac\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of natural Met-enkephalin and its analogues Tyr-D-Ala-Gly-Phe-Cys(Et) (I) and Tyr-D-Ala-Gly-Phe-Cys(Bu) (II) on serum rat prolactin and rat growth hormone levels in male rats has been studied. Met-enkephalin and both analogues increased serum growth hormone and prolactin concentration, analogue I being the most potent. Enkephalin analogue I, with isosteric isomer of methionine in Met-enkephalin, and analogue II with butyl residue showed a lower stimulatory effect than natural Met-enkephalin. Stimulatory effect of analogues I and II on prolactin and growth hormone release was found to be reversed by a simultaneous treatment with the opiate antagonist naloxone.</p>\",\"PeriodicalId\":11547,\"journal\":{\"name\":\"Endocrinologia experimentalis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrinologia experimentalis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinologia experimentalis","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本文研究了天然蛋氨酸脑啡肽及其类似物tyr - d - ala - gly - ph - cys (Et) (I)和tyr - d - ala - gly - ph - cys (Bu) (II)对雄性大鼠血清泌乳素和生长激素水平的影响。脑啡肽和两种类似物均能提高血清生长激素和催乳素浓度，其中类似物I的作用最强。脑啡肽类似物I(含蛋氨酸等构异构体)和类似物II(含丁基残基)的刺激作用低于天然脑啡肽。与阿片拮抗剂纳洛酮同时治疗，发现类似物I和II对催乳素和生长激素释放的刺激作用被逆转。
Effect of enkephalin analogues Tyr-D-Ala-Gly-Phe-Cys(Et) and Tyr-D-Ala-Gly-Phe-Cys(Bu) on prolactin and growth hormone release in rats.
The effect of natural Met-enkephalin and its analogues Tyr-D-Ala-Gly-Phe-Cys(Et) (I) and Tyr-D-Ala-Gly-Phe-Cys(Bu) (II) on serum rat prolactin and rat growth hormone levels in male rats has been studied. Met-enkephalin and both analogues increased serum growth hormone and prolactin concentration, analogue I being the most potent. Enkephalin analogue I, with isosteric isomer of methionine in Met-enkephalin, and analogue II with butyl residue showed a lower stimulatory effect than natural Met-enkephalin. Stimulatory effect of analogues I and II on prolactin and growth hormone release was found to be reversed by a simultaneous treatment with the opiate antagonist naloxone.
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