聚(庚嗪亚胺)钠催化的烯烃氧三氟甲基化反应用于合成 α-CF3 酮类

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC Journal of Organic Chemistry Pub Date : 2025-03-29 DOI:10.1021/acs.joc.5c00117

Chen Bao, Xinyu Zhu, Mengying Xu, Ming Hou, Peng Wang, Guanyinsheng Qiu

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摘要

本文报道了在光照射下烷基萘酸催化烯烃氧三氟甲基化反应。该反应适用于α-三氟甲基酮的合成，可以在结构上加工成一系列有用的支架。机理研究表明，光激发的NaPHI*可以通过EnT过程促进单线态1O2的形成，从而实现与三氟甲基自由基和氧自由基阴离子的双官能化。

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Sodium Poly(heptazine imide)-Enabled Oxytrifluoromethylation of Alkenes for the Synthesis of α-CF3 Ketones

This paper describes a NaPHI-catalyzed oxytrifluoromethylation of olefins under photoirradiation. The reaction is applicable for the synthesis of α-trifluoromethyl ketones, which could be structurally elaborated into an array of useful scaffolds. Mechanistic studies suggested that photoexcited NaPHI* could facilitate the formation of singlet ¹O₂ through an EnT process, thus enabling difunctionalization with trifluoromethyl radical and oxygen radical anion species.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.