发展为骨髓肿瘤的克隆性造血患者的临床病理特征和预后

IF 13.4 1区 医学 Q1 HEMATOLOGY Leukemia Pub Date : 2025-04-02 DOI:10.1038/s41375-025-02564-z
Kelly S. Chien, Julie S. Braish, Ziyi Li, Sanam Loghavi, Alex Bataller, Guillermo Montalban-Bravo, Koji Sasaki, Rashmi Kanagal-Shamanna, Koichi Takahashi, Courtney D. DiNardo, Mahesh Swaminathan, Hagop M. Kantarjian, Guillermo Garcia-Manero
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引用次数: 0

摘要

克隆造血(CH)是一种非恶性的克隆扩增的造血干细胞群体,由于获得体细胞突变(s),赋予自我更新和增殖的优势。这些突变已在健康个体中检测到,并随着正常的衰老而增加。随着年龄的增长,CH患病率的增加可能反映了暴露于环境应激源(如辐射、烟草和诱变药物)的累积效应,这些环境应激源为特定的造血干细胞提供了选择压力,从而导致克隆扩增bbb。虽然它的存在并不直接导致肿瘤疾病,但CH与血液恶性肿瘤和髓系肿瘤(MNs)、慢性炎症和心血管并发症的风险增加有关。克隆造血风险评分(CHRS)是一种结合年龄、外周血实验室值、特定突变和变异等位基因频率(VAF)的个性化预测工具,用于评估健康成人ch[4]进展为MNs的风险。病史的影响,特别是先前的癌症诊断和抗肿瘤治疗的暴露,不包括在内。此外,虽然已经确定CH增加了MN转化的风险,但进展为MN的CH患者的疾病演变动力学仍不清楚。因此,我们旨在评估已知既往CH的MN患者的临床病理特征和生存结果,特别关注既往非髓系恶性肿瘤患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Clinicopathologic characteristics and outcomes of patients with clonal hematopoiesis who progress to myeloid neoplasms
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来源期刊
Leukemia
Leukemia 医学-血液学
CiteScore
18.10
自引率
3.50%
发文量
270
审稿时长
3-6 weeks
期刊介绍: Title: Leukemia Journal Overview: Publishes high-quality, peer-reviewed research Covers all aspects of research and treatment of leukemia and allied diseases Includes studies of normal hemopoiesis due to comparative relevance Topics of Interest: Oncogenes Growth factors Stem cells Leukemia genomics Cell cycle Signal transduction Molecular targets for therapy And more Content Types: Original research articles Reviews Letters Correspondence Comments elaborating on significant advances and covering topical issues
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