吡咯衍生物的合成及其抑菌活性研究。(III - 2) - 4-arylpiperazino 3-ethoxycarbonyl-5-aryl-pyrrole衍生品。

Il Farmaco; edizione scientifica Pub Date : 1988-12-01

M T Cocco, C Congiu, A Maccioni, M L Schivo, A De Logu, G Palmieri

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摘要

合成了2位有芳基哌嗪基团的3-乙氧羰基-5-芳基吡咯衍生物。体外生物学研究表明，化合物(XVIII)对革兰氏阳性微生物和念珠菌均有较强的抑菌活性，而其他化合物均无明显的抑菌活性。

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Synthesis and antimicrobial activity of some pyrrole derivatives. III--2-(4-arylpiperazino)-3-ethoxycarbonyl-5-aryl-pyrrole derivatives.

The synthesis of 3-ethoxycarbonyl-5-aryl-pyrrole derivatives with an arylpiperazine group in position 2 is described. The in vitro biological investigation showed that compound (XVIII) had considerable antibacterial activity against gram-positive microorganisms and antifungal activity against Candida rugosa, while the other compounds did not show any significative activity.

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Il Farmaco; edizione scientifica

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