粪便菌群移植后复发性难辨梭菌感染避免过早使用抗生素。

IF 0.5 Q4 GASTROENTEROLOGY & HEPATOLOGY ACG Case Reports Journal Pub Date : 2025-04-03 eCollection Date: 2025-04-01 DOI:10.14309/crj.0000000000001660

Rahim A Burdette, Caroline C Whitt, Brian W Behm, Cirle A Warren

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引用次数: 0

摘要

复发性艰难梭菌感染（rCDI）仍然是一个主要的临床挑战，在常规治疗失败后通常需要粪便微生物群移植（FMT）。一名86岁的rCDI妇女在多种抗生素治疗失败后接受了FMT。FMT后不久，她出现腹泻和腹痛，并伴有艰难梭菌粪便检测阳性。由于临床改善，停用抗生素，患者在没有进一步治疗的情况下症状完全消退。该病例表明，在FMT后不久，对rCDI患者停用抗生素可能有好处，以便有足够的时间进行供体微生物群植入，并强调需要进一步研究以优化FMT后管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Avoiding Premature Antibiotic Use in Recurrent Clostridioides difficile Infection After Fecal Microbiota Transplant.

Recurrent Clostridioides difficile infection (rCDI) remains a major clinical challenge, often requiring fecal microbiota transplantation (FMT) after conventional treatment fails. An 86-year-old woman with rCDI underwent FMT after failing multiple antibiotic therapies. Shortly after FMT, she experienced diarrhea and abdominal pain, alongside positive C. difficile stool tests. Antibiotics were withheld because of clinical improvement, and she achieved complete resolution of symptoms without further treatment. This case demonstrates the potential benefit of withholding antibiotics in rCDI patients soon after FMT to allow sufficient time for donor microbiota engraftment and underscores the need for further research to optimize post-FMT management.

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.