{"title":"LGR信号和代谢调控：解决胰岛素抵抗和糖尿病治疗的新前沿。","authors":"Tomohisa Aoyama, Toshimasa Yamauchi","doi":"10.1111/jdi.70042","DOIUrl":null,"url":null,"abstract":"<p>LGR signaling plays a crucial role in metabolic regulation by coordinating muscle-neuron-adipose tissue crosstalk. In response to a high-sugar diet, muscle-derived BMP signaling activates neuronal Bursicon, which stimulates insulin secretion and enhances adipose insulin sensitivity. This evolutionarily conserved pathway underscores LGR4 as a promising therapeutic target for insulin resistance and diabetes.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 6","pages":"984-985"},"PeriodicalIF":3.0000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70042","citationCount":"0","resultStr":"{\"title\":\"LGR signaling and metabolic regulation: A new frontier in addressing insulin resistance and diabetes treatment\",\"authors\":\"Tomohisa Aoyama, Toshimasa Yamauchi\",\"doi\":\"10.1111/jdi.70042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>LGR signaling plays a crucial role in metabolic regulation by coordinating muscle-neuron-adipose tissue crosstalk. In response to a high-sugar diet, muscle-derived BMP signaling activates neuronal Bursicon, which stimulates insulin secretion and enhances adipose insulin sensitivity. This evolutionarily conserved pathway underscores LGR4 as a promising therapeutic target for insulin resistance and diabetes.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":51250,\"journal\":{\"name\":\"Journal of Diabetes Investigation\",\"volume\":\"16 6\",\"pages\":\"984-985\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70042\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Diabetes Investigation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jdi.70042\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes Investigation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jdi.70042","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
LGR signaling and metabolic regulation: A new frontier in addressing insulin resistance and diabetes treatment
LGR signaling plays a crucial role in metabolic regulation by coordinating muscle-neuron-adipose tissue crosstalk. In response to a high-sugar diet, muscle-derived BMP signaling activates neuronal Bursicon, which stimulates insulin secretion and enhances adipose insulin sensitivity. This evolutionarily conserved pathway underscores LGR4 as a promising therapeutic target for insulin resistance and diabetes.
期刊介绍：
Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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